Searchable abstracts of presentations at key conferences in endocrinology

ea0022p481 | Female reproduction | ECE2010

Serum concentrations of carboxylated osteocalcin are increased and associated with the components of the polycystic ovarian syndrome

Diamanti-Kandarakis Evanthia , Livadas Sarantis , Katsikis Ilias , Piperi Christine , Mantziou Aimilia , Papavassiliou Athanasios G , Panidis Dimitrios

Objective: Intriguing studies suggest that osteocalcin (OC) and its carboxylated (Gla)/uncarboxylated form are involved in the regulation of insulin secretion and action. Additionally, advanced glycated end products (AGEs), directly regulate the secretion of these osteoblast derived molecules. In PCOS among the pathophysiological aberrations, deregulation of insulin secretion and action as well as elevated AGEs levels have been demonstrated. In this study, we evaluated the ser...

ea0020p633 | Reproduction | ECE2009

Advanced glycosylated end products are associated with anovulatory markers in women with polycystic ovary syndrome

Diamanti-Kandarakis Evanthia , Piouka Athanasia , Livadas Sarantis , Piperi Christine , Katsikis Ilias , Papavasiliou Athanasios , Panidis Dimitrios

Background: Chronic anovulation constitutes one of the cardinal features of Polycystic Ovary Syndrome (PCOS) and Anti-Müllerian hormone (AMH), a granulosa cell product, is a well documented marker of anovulation. Recent data have shown that oxidative stress is involved in the pathophysiology of anovulation. A marker of oxidative stress, Advanced Glycosylated End products (AGEs), is implicated to the pathogenesis of the syndrome and have been localized with high intensity ...

ea0020p634 | Reproduction | ECE2009

A systematic review and a meta-analysis on adiponectin levels in women with polycystic ovary syndrome

Toulis Konstantinos , Goulis Dimitrios , Farmakiotis Dimitrios , Katsikis Ilias , Georgopoulos Neoklis , Tarlatzis Basil , Papadimas Ioannis , Panidis Dimitrios

Background: Conflicting results regarding adiponectin levels in women with polycystic ovary syndrome (PCOS) have been reported. To evaluate adiponectin levels in PCOS, a systematic review of all studies comparing adiponectin levels in women with PCOS to healthy controls and a meta-analysis of those involving women with similar Body Mass Index (BMI) were performed. Influence of possible effect modifiers, such as insulin resistance (IR) and testosterone, was investigated. Influe...

ea0016p254 | Diabetes and cardiovascular diseases | ECE2008

Increased serum AGEs is a distinct finding in lean women with PCOS

Diamanti-Kandarakis Evanthia , Katsikis Ilias , Piperi Christina , Kandaraki Eleni , Piouka Athanasia , Papavassiliou Athanasios , Panidis Dimitrios

In insulin resistant, young women with PCOS elevated serum AGEs and their receptor RAGE have been reported. The present study (approved by the local ethical committee) was undertaken to determine whether increased levels of serum AGEs in PCOS is a distinct finding compared with age- and BMI-matched women, presenting the isolated components of the syndrome and whether serum AGE levels were different among PCOS phenotypes. A total of 193 lean non-insulin resistant women were stu...

ea0020p489 | Obesity and Metabolism | ECE2009

Effect of pharmaceutical intervention on serum levels of advanced glycated end products in women with polycystic ovary syndrome

Diamanti-Kandarakis Evanthia , Christakou Charikleia , Piperi Chistina , Kandaraki Eleni , Katsikis Ilias , Adamopoulos Christos , Papavasiliou Athanasios G , Panidis Dimitrios

Background: Polycystic ovary syndrome (PCOS) is associated with obesity and insulin resistance, two major contributors to cardiovascular risk. Even in the absence of detectable insulin resistance, lean, non-diabetic PCOS women demonstrate increased circulating levels of advanced glycated end products (AGEs), known proatherogenic molecules. This adverse cardiovascular risk profile should be considered in the syndrome’s management.Objective: To invest...