Searchable abstracts of presentations at key conferences in endocrinology

ea0019p314 | Steroids | SFEBES2009

The adipokine, Pre-B cell colony enhancing factor (PBEF)/visfatin, activates steroidogenic acute regulatory protein (StAR) protein expression and steroid production in human adrenocortical-H295R-cells via MAPK and PI3/AkT signalling pathways

Kaur Jaspreet , Ramanjaneya Manjunath , Chen Jing , Randeva Harpal

PBEF/Visfatin is an adipokine highly enriched in adipose tissue which is increased in obesity and has been shown to be involved in numerous physiological processes. The adrenal gland plays a pivotal role in the integration of metabolic activity and energy balance, through production of steroids, mainly glucocorticoids. Steroidogenesis is a tightly controlled and essential process, which is mediated by steroidogenic acute regulatory protein (StAR), a protein that transports cho...

ea0019oc23 | Cardiovascular metabolism | SFEBES2009

Insulin increases and metformin decreases the novel adipokine chemerin in insulin resistant subjects: PCOS as a paradigm

Tan Bee , Chen Jing , Adya Raghu , Kaur Jaspreet , Heutling Dennis , Lewandowski Krzysztof C , Lehnert Hendrik , Randeva Harpal

Adipose tissue produces several hormones and cytokines termed ¬Ďadipokines¬í that have widespread effects on carbohydrate and lipid metabolism. They appear to play an important role in the pathogenesis of insulin resistance, diabetes, and atherosclerosis. Chemerin is a novel adipokine, highly expressed in obese, insulin-resistant subjects. Polycystic ovary syndrome (PCOS) is associated with insulin resistance and obesity. We assessed chemerin levels in sera and adipose...

ea0050p211 | Diabetes and Cardiovascular | SFEBES2017

Nuclear factor-kappa beta activation and monocyte-endothelial adhesion lead to chemerin induced endothelial cell inflammation

Dimitriadis Georgios K , Kaur Jaspreet , Mytilinaiou Maria , Davasgaium Allan , Sambrook Diane , Hewins Claire , Nalawade Nilisha , Miras Alexander D , Randeva Harpal S

Chemerin, a chemoattractant protein, acts via a G-protein coupled chemokine receptor, i.e. Chemokine like Receptor 1/ChemR23; levels of which are elevated in pro-inflammatory states such as obesity and type 2 diabetes mellitus (T2DM). Obesity and T2DM patients are at high risk of developing cardiovascular disorders such as atherosclerosis. We have reported that chemerin induces human endothelial cell angiogenesis and since dy...

ea0050p211 | Diabetes and Cardiovascular | SFEBES2017

Nuclear factor-kappa beta activation and monocyte-endothelial adhesion lead to chemerin induced endothelial cell inflammation

Dimitriadis Georgios K , Kaur Jaspreet , Mytilinaiou Maria , Davasgaium Allan , Sambrook Diane , Hewins Claire , Nalawade Nilisha , Miras Alexander D , Randeva Harpal S

Chemerin, a chemoattractant protein, acts via a G-protein coupled chemokine receptor, i.e. Chemokine like Receptor 1/ChemR23; levels of which are elevated in pro-inflammatory states such as obesity and type 2 diabetes mellitus (T2DM). Obesity and T2DM patients are at high risk of developing cardiovascular disorders such as atherosclerosis. We have reported that chemerin induces human endothelial cell angiogenesis and since dy...