Searchable abstracts of presentations at key conferences in endocrinology

ea0050p191 | Clinical Biochemistry | SFEBES2017

An audit of the management of patients presenting with hyponatraemia

Kearney Jessica , Kumar Sathis

Introduction: Hyponatraemia is the most common electrolyte disturbance, affecting 15–20% of emergency admissions to hospital. It is associated with increased mortality and length of stay in hospital. This audit was performed to evaluate how well hyponatraemia is being investigated and managed in the Acute Assessment Unit (AAU).Methods: Sodium level on admission for all patients attending AAU at Conquest Hospital over a 1-...

ea0050p191 | Clinical Biochemistry | SFEBES2017

An audit of the management of patients presenting with hyponatraemia

Kearney Jessica , Kumar Sathis

Introduction: Hyponatraemia is the most common electrolyte disturbance, affecting 15–20% of emergency admissions to hospital. It is associated with increased mortality and length of stay in hospital. This audit was performed to evaluate how well hyponatraemia is being investigated and managed in the Acute Assessment Unit (AAU).Methods: Sodium level on admission for all patients attending AAU at Conquest Hospital over a 1-...

ea00100oc8 | Oral Communications | SFEEU2024

Dexamethasone-suppressed PET CT, using an 18F-ligand (‘CETO’), allows non-invasive diagnosis of unilateral aldosterone-producing adenoma, and prediction of complete clinical cure after adrenalectomy

Kearney Jessica , Goodchild Emily , Wu Xilin , Cheow Heok , Gurnell Mark , Drake William , Brown Morris J

Case History: A 57-year-old lady was referred with a 6-year history of hypertension and hypokalaemia necessitating hospital admission. Her medical background included breast cancer managed with chemotherapy, radiotherapy and surgery. She required Eplerenone 50 mg OD and Amlodipine 5 mg to control her hypertension, and Sando-K 2 tablets TDS to maintain normokalaemia. The patient was enrolled into the MATCH trial comparing adrenal vein sampling (AVS) with [11C]-metomi...

ea00100p37 | Poster Presentations | SFEEU2024

PET CT and ultrasound-guided endoscopic radiofrequency ablation: almost a one-stop, minimally-invasive cure for hypertension due to an aldosterone-producing adenoma

Kearney Jessica , Goodchild Emily , Wu Xilin , Goodchild George , Cheow Heok , Gurnell Mark , Drake William , Brown Morris

Case history: A 39-year-old gentleman was referred to the Endocrine clinic with a 5-year history of hypertension and intermittent hypokalaemia. He had been seen in the hypertension clinic, screened for secondary causes, and found to have an aldosterone of 604 pmol/l, renin <0.2 nmol/l/hr and potassium 3.7 mmo/l (off interfering medication), in-keeping with a diagnosis of Primary Aldosteronism (PA). His blood pressure was 126/82 mmHg on Ramipril 10 mg, Amlodipine 5 mg OD an...

ea0050p205 | Diabetes and Cardiovascular | SFEBES2017

The effect of escalating doses of beta-blockers and ACE inhibitors on mortality in patients with heart failure and diabetes mellitus

Kearney Jessica , Walker Andrew , Patel Peysh , Drozd Michael , Witte Klaus , Slater Thomas , Kearney Lorraine , Kearney Mark , Cubbon Richard

Introduction: Diabetes mellitus (DM) is a common co-morbidity in patients with heart failure and reduced left ventricular ejection fraction (HF-REF), and is associated with adverse prognosis. Subgroup analyses of randomized controlled trials suggest patients with DM benefit prognostically from beta-adrenoreceptor blockers (BB) and angiotensin converting enzyme inhibitors (ACEi). However, it remains unclear whether escalating doses of these age...

ea0050p205 | Diabetes and Cardiovascular | SFEBES2017

The effect of escalating doses of beta-blockers and ACE inhibitors on mortality in patients with heart failure and diabetes mellitus

Kearney Jessica , Walker Andrew , Patel Peysh , Drozd Michael , Witte Klaus , Slater Thomas , Kearney Lorraine , Kearney Mark , Cubbon Richard

Introduction: Diabetes mellitus (DM) is a common co-morbidity in patients with heart failure and reduced left ventricular ejection fraction (HF-REF), and is associated with adverse prognosis. Subgroup analyses of randomized controlled trials suggest patients with DM benefit prognostically from beta-adrenoreceptor blockers (BB) and angiotensin converting enzyme inhibitors (ACEi). However, it remains unclear whether escalating doses of these age...

ea0086p194 | Endocrine Cancer and Late Effects | SFEBES2022

The incidence and clinical significance of metabolically active brown adipose tissue in patients with pheochromocytomas and paragangliomas: A retrospective cohort study, systematic review and meta-analysis

Onyema Michael , Ostarijas Eduard , Minhas Raisa , Roy Aparajita , Kearney Jessica , Omran Asma , Zair Zoulikha , Reynolds Saira , Mulholland Nicola , Corcoran Benjamin , Halim Mohammad , Aylwin Simon , Dimitriadis Georgios K

There is limited research into the impact of active brown adipose tissue (aBAT) in patients with phaeochromocytomas and paragangliomas (PPGLs). A small body of evidence has shown that patients with PPGL patients can exhibit a high prevalence for aBAT recognized as ranging between 8 - 28% without specific correlation to germline mutations. Furthermore, it has been suggested that aBAT may be linked to increased mortality. Systematic searches of the Medical Literature Analysis an...

ea0099p515 | Pituitary and Neuroendocrinology | ECE2024

Body weight in acromegaly – does it make any difference?

Kaniuka-Jakubowska Sonia , higham claire , Davis Jessica , Kearney Tara , Loughrey Paul , Elamin Aisha , Flanagan Daniel , Kaszubowski Mariusz , Ayuk John , M Orme Steve , Wass John

Introduction: IGF-1 dependence on sex is a well-known fact; however, whether IGF-1 is also influenced by body weight is still questionable, and the mechanism of a potential relationship between GH, IGF-1 and body weight is not fully explained. The effect of gender (or rather oestrogens) on IGF-1 is visible in acromegaly - women are diagnosed at an older age than men (approximately 4 years) (potentially by suppressive effect on the axis of GH-IGF-1). The aim of the study was to...

ea00100p23 | Poster Presentations | SFEEU2024

The adrenal puzzle: cure in primary aldosteronism

Pineau Mitchell Antonine , Goodchild Emily , Wu Xilin , Kearney Jessica , Wozniak Eva , Cabrera Claudia , Cheow Heok , M. Drake William , J. Brown Morris

Section 1: Case history: A 42-year-old man was referred with a five-year history of hypertension and multiple hospital admissions for hypokalaemia. His blood pressure was 164/104 mmHg on three drugs.Section 2: Investigations: A diagnosis of primary aldosteronism (PA) was confirmed on a saline suppression test: aldosterone 554 pmol/l at baseline, 240 pmol/l post saline infusion (normal <170). A CT adrenal revealed a 13 mm left-sided adrenal nodule. Th...