Searchable abstracts of presentations at key conferences in endocrinology

ea0049s19.2 | How to incorporate the new guidelines for thyroid cancer in my clinical practice | ECE2017

When and how should we perform extensive surgery?

Kebebew Electron

Thyroid cancer is one of the most rapidly increasing cancer diagnoses worldwide. Thyroid cancers exhibit the full range of cancer behavior from the relatively indolent occult papillary thyroid cancer to the uniformly aggressive and lethal undifferentiated thyroid cancers. Surgical resection is the principal treatment for thyroid cancer and there are several important areas of controversy in the surgical management of thyroid cancer. Some of these controversies have arisen due ...

ea0049gp186 | Pituitary & endocrine Tumours | ECE2017

24 hour urinary 5-hydroxyindoleacetic acid (5-HIAA) doubling-time (DT) is associated with disease-specific mortality (DSM) and progression-free survival (PFS) in patients with neuroendocrine tumors (NETs)

Tirosh Amit , Nilubol Naris , Patel Dhaval , Kebebew Electron

Background: Biochemical biomarker DT is used clinically for prognosis prediction in several solid malignancies. The aim of the current analysis was to determine whether biomarker DT has any prognostic utility in patients with NETs.Methods: Patients with NETs (n=184) were enrolled in a prospective study with comprehensive biochemical analysis. The current analysis included subjects with increasing 5-HIAA levels in at least two consecutive measure...

ea0056gp225 | Thyroid Cancer - Diagnostics & Treatments | ECE2018

Germline mutations in KIF1B gene in two families with familial non-medullary thyroid cancer (FNMTC)

Anon Aida Orois , Porta Mireia Mora , Rabinovich Irene Halperin , Gara Sudheer Kumar , Kebebew Electron , Ambros Josep Oriola

Introduction: Familial non-medullary thyroid cancer(FNMTC) represents 3–9% of thyroid cancer cases. Although the susceptibility genes for syndromic FNMTC are known, most cases of FNMTC are nonsyndromic and the genetic causes are unknown.Patients and methods: We conducted a multicenter study to identify a candidate susceptibility gene for nonsyndromic FNTMC. We collected blood specimens, clinical and pathological data from 38 kindreds with FNMTC (32 ...

ea0049gp124 | Endocrine Tumours | ECE2017

VHL Genotype and risk stratification of pancreatic neuroendocrine tumors in patients with von hippel-lindau disease

Tirosh Amit , Shell Jasmine , Green Patience , Keutgen Xavier M. , Sadowski Samira M. , Lakis Mustapha el , Nockel Pavel , Patel Dhaval , Nilubol Naris , Kebebew Electron

Background: About 8–20% of patients with von Hippel-Lindau disease (vHLd) develop pancreatic neuroendocrine tumors (PNETs). However, prognostic markers for these tumors are lacking. The VHL gene mutation type is associated with the clinical phenotype of vHLd. Hence, we aimed to determine whether VHL mutation characteristics may be associated with PNETs phenotype in patients with vHLd.Methods: A prospective study of patients with vHLd and PNETs with ...

ea0049oc7.3 | Cardiovascular endocrinology (1) | ECE2017

High Total 68Ga-DOTATATE-Avid Tumor Volume (TV) is associated with low progression-free survival and high disease-specific mortality rate in patients with neuroendocrine tumors

Tirosh Amit , Papadakis Georgios Z. , Millo Corina , Sadowski Samira M. , Herscovitch Peter , Pacak Karel , Marx Stephen J. , Yang Lily , Nockel Pavel , Shell Jasmine , Green Patience , Keutgen Xavier M. , Patel Dhaval , Nilubol Naris , Kebebew Electron

Background: Patients with neuroendocrine tumors (NETs) have divergent survival, even when having the same site of primary tumor, and tumor stage and grade. 68Gallium (68Ga)-DOTATATE positron emission tomography (PET)/computed tomography (CT) is a sensitive imaging modality for detecting NETs. The purpose of this study was to determine whether 68Ga-DOTATATE PET/CT imaging has any prognostic utility in patients with NETs.Methods: One hundred and eighty-fou...

ea0037oc1.1 | Adrenal 1 | ECE2015

PRKACA defects and cortisol-producing lesions of the adrenal cortex: specific clinical phenotypes and histological features

Angelousi Anna , Salpea Paraskevi , Faucz Fabio , Zilbermint Michail , London Edra , Libe Rossella , Espiard Stephanie , Lyssikatos Charalampos , Kelestimur Fahrettin , Kebebew Electron , Delemer Brigitte , Hieronimus Sylvie , Feve Bruno , Raverot Gerald , Bertherat Jerome , Stratakis Constantine

Introduction: Germline inactivating mutations of the protein kinase A (PKA) regulatory subunit RIα (the PRKAR1A gene) cause primary pigmented nodular adrenocortical disease (PPNAD); other cyclic AMP (cAMP) signalling defects have been associated with bilateral adrenocortical hyperplasia (BAH), cortisol-producing adenoma (CPA) and related lesions. Recently, PRKACA somatic mutations were detected in single, sporadic CPAs in approximately 40% of patients wi...