Searchable abstracts of presentations at key conferences in endocrinology

ea0065p357 | Reproductive Endocrinology and Biology | SFEBES2019

Deciphering the effects of testosterone on FSH glycosylation variant-dependent ERK/MAPK activation

Kellaway Jedidiah , Bousfield George , Jonas Kim

The heterodimeric glycoprotein hormone, follicle stimulating hormone (FSH) and its receptor (FSHR) are vital for reproductive function, driving ovarian function via follicular recruitment, selection and development. FSH exists as two predominant glycoforms in females; partially glycosylated (FSH21) and fully glycosylated (FSH24), based on differing glycosylation patterns of the β subunit. The FSH glycoforms have different bioactivities, with FSH21 displaying a higher bind...