Searchable abstracts of presentations at key conferences in endocrinology

ea0020oc2.2 | Diabetes & Obesity | ECE2009

Thymocyte migration is impaired in NOD mice: combined role of extracellular matrix and chemokines

Mendes-da-Cruz Daniella , Bauer Moises , Smaniotto Salete , Keller Alexandre , Savino Wilson , Dardenne Mireille

The NOD (non-obese diabetic) mouse remains the best experimental model of type I diabetes. We have previously described several thymic dysfunctions in these animals, including the presence of giant perivascular spaces (PVS) with arrest of mature T cells (including Treg cells) and partial impairment on fibronectin/VLA-5-dependent NOD thymocyte migration. Herein, we further studied the role of extracellular matrix (ECM) ligands, alone or in combination with the chemokine CXCL12 ...