Endocrine Abstracts

Objectives: To determine the prevalence/aetiology/clinical significance of pituitary dysfunction following moderate/severe childhood traumatic brain injury (TBI).Subjects: Twenty-six survivors of childhood TBI (20 males). Age at study: 5.4–18.9 year (median 13 year). Median time since TBI: 4.5y (2.3–6.7 year). King’s outcome scale for childhood head injury (KOSCHI) rating: 11 good recovery, 15 moderate disability, two severe disability.</p...

Background: Congenital adrenal hyperplasia (CAH) is a recessively inherited deficiency of cortisol production associated with life-threatening adrenal crisis, accelerated growth and excess virilising hormone production, which may result in girls being incorrectly assigned as boys at birth. Newborn screening for CAH has not been introduced in the UK, reflecting concerns about false positive diagnoses, as well as inconsistent information about disease frequency and severity. A n...

Objectives: To determine the prevalence and clinical significance of pituitary dysfunction following moderate/severe childhood traumatic brain injury (TBI).Subjects and methods: We recruited 25 survivors of childhood TBI (19 males). Age at study was 5.4–18.9y (median 13.0y). Median time since TBI: 4.4y (2.3–6.7y). Subjects provided an early morning urine sample for osmolality and underwent basal hormone evaluation at 0800–1000h, followed b...

Context: In rodents, in-utero exposure to the exogenous oestrogen diethylstilboestrol (DES) results in reproductive abnormalities in male offspring. It has been proposed that similar anti-androgenic effects also occur in the human fetal testis following oestrogen exposure.Objective: Determine effects of DES exposure on testosterone production by normally growing human fetal testis xenografts.Design: Human fetal testes (15&...

Aims: To compare the effect of a standard Sex Steroid Regimen (sSSR) with a physiological SSR (pSSR) on androgen status in young women with premature ovarian failure (POF).Patient Population: Seven women with POF were evaluated for the study. The median age was 28 years (range 21–36) and the median duration of ovarian failure was 14 years (range 4–25).Methods: An open label randomised, controlled, crossover study over 28 ...