Searchable abstracts of presentations at key conferences in endocrinology

ea0031p353 | Thyroid | SFEBES2013

Low frequency of pendrin autoantibodies detected using a radioligand binding assay in patients with autoimmune thyroid disease

Kemp Elizabeth , Sandhu Harpreet , Weetman Anthony

Context: Pendrin is a transmembrane protein located at the apical end of the thyrocyte where it mediates the efflux of iodide through the thyroid follicular cell. Recently, pendrin was described as a significant antibody target in Japanese patients with Graves’ disease or autoimmune hypothyroidism using an immunoblotting assay. However, a subsequent study failed to verify this in autoimmune thyroid disease patients of Tunisian origin.Objective: The ...

ea0073pep13.8 | Presented ePosters 13: Pituitary and Neuroendocrinology | ECE2021

Use of antisense oligonucleotides as a therapy for Cushing’s disease

Kemp Elizabeth , Eltumi Hanan , Whatmore Jacob , John Newell-Price

BackgroundCushing’s disease (CD) is caused by high levels of blood cortisol resulting from excess secretion of adrenocorticotropic hormone (ACTH) from an anterior pituitary corticotroph adenoma. Clinical manifestations include diabetes, hypertension, osteoporosis, and depression. If untreated, CD has an increased mortality of five-fold owing to cardiovascular comorbidities, stroke or raised vulnerability to infection. Currently, transsphenoidal surg...

ea0059p125 | Neuroendocrinology and pituitary | SFEBES2018

Anti-POMC siRNA reduces ACTH secretion in an in vitro model of Cushing’s disease

Alzahrani Ahmed , Foulkes Elizabeth , Porter Julie , Kemp Elizabeth , Newell-Price John

Context: Cushing’s disease (CD) results from the release of high levels of adrenocorticotrophic hormone (ACTH) from a pituitary adenoma. Increased ACTH secretion stimulates excess cortisol production, causing weight gain, hypertension, diabetes and depression. The only curative treatment is transsphenoidal surgery, but the rate of recurrence is high and there is a lack of suitable medical therapies. RNA-interference is a mechanism of post-transcriptional gene silencing th...

ea0022p224 | Clinical case reports and clinical practice | ECE2010

Graves' disease, systemic lupus erythematosus, hypoparathyroidism: autoimmune polyglandular syndrome or coincidence?

Melcescu Eugen , Kemp Elizabeth H , Majithia Vikas , Vijayakumar Vani , Uwaifo Gabriel I , Koch Christian A

Data on coexisting Graves’ disease (GD), systemic lupus erythematosus (SLE), and hypoparathyroidism (hypop) are limited. Scanty case reports have described hypoparathyr or hypothyroidism (late complication) following external irradiation to the neck. The thyroid and parathyroid glands may be sensitive to the immunologic or irradiation damage.A 34-year old AA woman presented with tetanic-like cramps, easy skin bruising, fatigue, weight gain, nocturia...

ea0013p292 | Thyroid | SFEBES2007

The calcium-sensing receptor is a target of autoantibodies in patients with autoimmune polyendocrine syndrome type 1

Gavalas Nikos , Kemp Elizabeth , Krohn Kai , Brown Edward , Watson Philip , Weetman Anthony

Autoimmune polyendocrine syndrome type 1 (APS1) is a rare autosomal recessive disorder caused by mutations in the autoimmune regulator gene. Major disease components include mucocutaneous candidiasis, hypoparathyroidism and Addison’s disease. Acquired hypoparathyroidism (AH) occurs in 80% of APS1 patients and is associated with hypocalcaemia, hyperphosphataemia and low serum levels of parathyroid hormone (PTH). Reports suggest that these clinical symptoms are initiated by...

ea0034p382 | Thyroid | SFEBES2014

Prevalence and clinical associations of calcium-sensing receptor autoantibodies in finnish APECED patients

Habibullah Mahmoud , Kemp Elizabeth H , Kluger Nicolas , Ranki Annamari , Sandhu Harpreet K , Krohn Kai J E , Weetman Anthony P

Context: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is caused by mutations in the autoimmune regulator (AIRE) gene and is characterised by the presence of chronic mucocutaneous candidiasis, hypoparathyroidism and Addison’s disease. Patients typically display organ-specific autoantibodies which correlate with a particular clinical manifestation. Previous studies have identified the parathyroid-expressed calcium-sensing receptor (CaSR) as an aut...