ea0019p161 | Diabetes, Metabolism and Cardiovascular | SFEBES2009
, Wong Steve
, Kerrigan David
, Pinkney Jonathan
, Wilding John
Background: Adipose-tissue (AT)-derived cytokines contribute to systemic inflammation and insulin resistance. The systemic inflammation observed in obesity is thought to be mainly derived from the stromavascular fraction of adipose tissue due to macrophage-infiltration of AT in obesity. Macrophages are thought to be recruited and trapped in AT by release of chemoattractant-molecules such as monocyte-chemoattractant-protein-1 (MCP-1) and macrophage-migration-inhibitory-fa...