Searchable abstracts of presentations at key conferences in endocrinology

ea0026p332 | Obesity | ECE2011

Effects of food, hormones and autonomic nervous activity on rhythmic expression of clock genes and metabolic genes in rat white adipose tissue

van der Spek R , Kervezee L , La Fleur S , Fliers E , Kalsbeek A

Background: Shift workers and rodents with clock gene mutations show increased risk of metabolic syndrome and type 2 diabetes (T2DM). Conversely, obesity and T2DM are related to circadian disturbances in humans and rodents. The circadian release of adipokines from white adipose tissue (WAT) plays a pivotal role in energy metabolism. Its regulatory mechanism is unclear at present.Aim: To determine the daily expression patterns of genes involved in circadi...