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ea0029oc17.5 | Diabetes Basic | ICEECE2012

Glucocorticoid receptor α expression is downregulated in gluteal subcutaneous adipose tissue of black South African women and associates with increased metabolic risk

Goedecke J. , Stimson R. , Livingstone D. , Hayes P. , Adams K. , Dave J. , Keswell D. , Evans J. , Victor H. , Lambert E. , Levitt N. , Kahn S. , Olsson T.

Introduction: Increased capacity for glucocorticoid regeneration in subcutaneous adipose tissue (SAT) by 11β-hydroxysteroid dehydrogenase-1 (11HSD1) is associated with obesity and associated risk factors. We hypothesised that down-regulation of SAT 11HSD1 and/or glucocorticoid receptor-α (GRα) may explain differences in body fat distribution and metabolic risk between black and white women. The study aimed to compare the expression of 11HSD1 and glucocorticoid r...

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Endocrine Abstracts

Glucocorticoid receptor α expression is downregulated in gluteal subcutaneous adipose tissue of black South African women and associates with increased metabolic risk

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