Searchable abstracts of presentations at key conferences in endocrinology

ea0089b7 | Basic Science | NANETS2022

All-Trans Retinoic Acid Radiosensitizes Neuroendocrine Tumor Cells via Peptidyl-Prolyl Cis-Trans Isomerase 1 Inhibition

Williams Jelani K. , Schwarz Jason L. , Lakiza Olga , Kron Stephen , Weichselbaum Ralph R , Keutgen Xavier M.

Background: Peptide receptor radionuclide therapy (PRRT) is a promising radiation-based therapy for metastatic neuroendocrine tumors (NETs) but remains palliative. Peptidyl-prolyl cis-trans isomerase (Pin1) is an evolutionally conserved enzyme that catalyzes the cis-trans isomerization of phosphorylated serine/threonine-proline motifs of its substrates and has recently been involved in DNA double strand break (DSB) repair in BRCA-proficient breast cancer cells. Here we study w...

ea0089b10 | Basic Science | NANETS2022

Inhibition of Estrogen Receptor Alpha Radiosensitizes Neuroendocrine Tumors

Schwarz Jason L. , Williams Jelani K. , Lakiza Olga , Kron Stephen J. , Weichselbaum Ralph R. , Keutgen Xavier M.

Background: The use of peptide receptor radionuclide therapy (PRRT) for neuroendocrine tumors (NETs) is increasing, but PRRT remains palliative at this time. Estrogen (E2) has been extensively linked to cellular proliferation and DNA repair in other cancers. Our aim is to determine whether NET cells are similarly affected by estrogen and whether inhibition of estrogen receptor alpha (ESR1) increases radiosensitivity of NET cells, which could improve PRRT response.<p class=...

ea0049gp124 | Endocrine Tumours | ECE2017

VHL Genotype and risk stratification of pancreatic neuroendocrine tumors in patients with von hippel-lindau disease

Tirosh Amit , Shell Jasmine , Green Patience , Keutgen Xavier M. , Sadowski Samira M. , Lakis Mustapha el , Nockel Pavel , Patel Dhaval , Nilubol Naris , Kebebew Electron

Background: About 8–20% of patients with von Hippel-Lindau disease (vHLd) develop pancreatic neuroendocrine tumors (PNETs). However, prognostic markers for these tumors are lacking. The VHL gene mutation type is associated with the clinical phenotype of vHLd. Hence, we aimed to determine whether VHL mutation characteristics may be associated with PNETs phenotype in patients with vHLd.Methods: A prospective study of patients with vHLd and PNETs with ...

ea0049oc7.3 | Cardiovascular endocrinology (1) | ECE2017

High Total 68Ga-DOTATATE-Avid Tumor Volume (TV) is associated with low progression-free survival and high disease-specific mortality rate in patients with neuroendocrine tumors

Tirosh Amit , Papadakis Georgios Z. , Millo Corina , Sadowski Samira M. , Herscovitch Peter , Pacak Karel , Marx Stephen J. , Yang Lily , Nockel Pavel , Shell Jasmine , Green Patience , Keutgen Xavier M. , Patel Dhaval , Nilubol Naris , Kebebew Electron

Background: Patients with neuroendocrine tumors (NETs) have divergent survival, even when having the same site of primary tumor, and tumor stage and grade. 68Gallium (68Ga)-DOTATATE positron emission tomography (PET)/computed tomography (CT) is a sensitive imaging modality for detecting NETs. The purpose of this study was to determine whether 68Ga-DOTATATE PET/CT imaging has any prognostic utility in patients with NETs.Methods: One hundred and eighty-fou...

ea0098b14 | Basic Science | NANETS2023

Scandium-43-DOTATATE, a Novel Positron Emission Tomography (PET) Tracer for Neuroendocrine Tumor Imaging

Zhang Hannah J. , Pusateri Antonino J. , Meier Jason P. , Lakiza Olga , Bhuiyan Mohammed , Tsai Hsiu-Ming , Leoni Lara , Ghosh Kaustab , Freifelder Richard , Andy Liao Chih-Yi , Pu Yonglin , Appelbaum Daniel , Weichselbaum Ralph , Nolen Jerry , Kao Chien-Min , Rotsch David , Chen Chin-Tu , Keutgen Xavier M.

Background: Neuroendocrine tumors (NETs) represent a heterogenous group of neoplasms and their diagnosis can be challenging. In 2019, FDA approved 68Gallium labeled DOTATATE PET tracer for SSTR2 overexpressing NETs, which has been widely adopted since. However, limitations of 68Ga-DOTATATE have led to the development of additional radiotracers for the diagnosis of NETs. Herein we report on a novel PET tracer using 43Sc for DOTATATE labeling. <s...