ea0015p321 | Steroids | SFEBES2008
Heald Adrian
, Qureshi Zubair
, Khan Azhar
, Waldron Julian
, Davies Marten
, Taylor Norman
, Kane John
Background: Virilising congenital adrenal hyperplasia (CAH) is the most common cause of genital ambiguity, and 9095% of CAH cases are caused by 21-hydroxylase deficiency. Associated inefficient cortisol synthesis results in increased CRH and ACTH levels, leading to production of excess sex hormone precursors. These are further metabolized to active androgens and to a lesser extent oestrogens. We recently reported that one of these androgens, DHEA-S or its metabolites sig...