Endocrine Abstracts

Background: Glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2), are key products of the L-cell proglucagon-gene with diverse effects on metabolism. Whereas GLP-1 has been extensively studied, much less attention has been devoted to GLP-2. The current study directly compares the impact of GLP-1 and GLP-2 on pancreatic beta-cell function and turnover in vitro, as well as the effects on glucose tolerance and appetite suppression in mice.<p class="abs...

Background/Aims: Emerging evidence suggests that gut hormones interact with the reproductive axis and impact fertility in females. Here we combine three major gut hormones glucose-dependent insulinotropic peptide (GIP), glucagon (GCG) and glucagon-like peptide-1 (GLP-1), as a triple-agonist (TA) to elucidate its effects on female reproductive function.Methods: Female Swiss TO-mice (n = 6) on high-fat diet (HFD) or normal diet (ND) for 18-weeks r...

Background: Glucose-dependent insulinotropic polypeptide (GIP) secreted by K-cells in the intestine is an incretin that stimulates insulin secretion from pancreatic beta-cells. The aim of this study is to explore the extra-pancreatic effects of GIP on male fertility using diet-induced obese mice.Methods: Male Swiss TO-mice (n = 8) on high-fat diet (HFD) or normal diet (ND) for 8-weeks received twice-daily intraperitoneal injections of (...

Background/aims: Obesity is a major risk factor for endometrial cancer with estrogens in combined oral contraceptives enhancing the severity of the disease. This study aims to explore the effect of synthetic estrogen ethinylestradiol (EE2) commonly used in oral contraceptives, on endometrial morphology and regulatory markers in diet-induced obese mice.Methods: Female TO mice were on a high-fat diet (HFD) for 27 weeks. Three groups (n = 5) were g...