Endocrine Abstracts

Untreated hypothyroidism in pregnancy is associated with severe neurodevelopmental delay. Based on rodent experiments, maternal T3 is said not cross the placenta and to have little if any role in fetal brain development.Case report: A 36-year-old female with known hypothyroidism treated only with liothyronine (T3) 20 μg TDS. attended the antenatal clinic. It was suggested that she changed to treatment with levothyroxine (T4) or a combination of T3 a...

A 60 year old Caucasian woman was referred to endocrine clinic with persistent hypercalcaemia between 2.8 and 2.9 mmol/l (2.2–2.6), with inappropriately normal PTH at 7 pmol/l (1.48–7.63). Her hypercalcaemia was noted first in 2008. She had no signs or symptoms associated with hypercalcemia. However, she has a strong family history of hypercalcaemia, where her mother required Cinacalcet to control her hypercalcaemia despite two previous parathyroid resections. She ha...

We report a 77 year old male who presented to the respiratory clinic with episodes of periodic sweating. These episodes were associated nausea. They came on with exercise and always occurred before meals. The resolving factor noted by the patient was food intake and no features suggestive of reactive hypoglycaemia were noted. His past medical history was significant for hypertension, mild bronchiectasis, mild to moderate obstructive sleep apnea requiring CPAP therapy and ische...

Background: Radioiodine treatment (RIT) for benign functioning thyroid disease is an effective treatment for patients with hyperthyroidism. The safety, preparation, administration and follow-up of treatment demands time and organisation. The planning of this elective treatment is affected by the patient’s availability which makes adequate and timely treatment of the subsequent hypothyroidism challenging. A quality improvement project was therefore set up to mitigate this....

Background: Radioiodine treatment (RIT) for benign functioning thyroid disease is an effective treatment for patients with hyperthyroidism. The safety, preparation, administration and follow-up of treatment demands time and organisation. The planning of this elective treatment is affected by the patient’s availability which makes adequate and timely treatment of the subsequent hypothyroidism challenging. A quality improvement project was therefore set up to mitigate this....

Case history: A 32 year old female was admitted for an elective gynaecological procedure LLETZ (large loop excision of the transformation zone) under general anaesthesia as per patient”s request. An uncomplicated LLETZ procedure was performed. Post operatively, patient was found to be tachycardiac and had severe palpitations with nausea. She then reported that she had recently lost a significant amount of weight, had been suffering with anxiety, palpitations, and tremors ...

Case presentation: A 66 year old male presented to the clinical physiology department for a routine ECHO. He was found to be hemodynamically unstable with fast Atrial fibrillation and was referred to ED for immediate management. He was subsequently admitted in CCU under Cardiology. He presented with a 3 month history of shortness of breath, palpitations, persistent tremors, unintentional weight loss and generalised fatigue. No previous thyroid problems. He had a longstanding h...

A 48 years old lady with BMI of 46kg/m2 was postmenopausal since age 45. Due to abdominal discomfort she had an abdominal CT, which incidentally identified bilateral adrenal adenoma (9 mm on right, 18 mm on left, with fat content). This resulted in Endocrinology referral and a history of gradually worsening hirsuitism was uncovered. Her hyperandrogenism was confirmed biochemically with markedly elevated testosterone at 6.5 nmol/l (0.0–1.8), leading to a search ...

Overt hyperthyroidism occurs in about 0.1–0.4% of all pregnancies. Propylthiouracil (PTU) is recommended in first trimester due to risk of teratogenicity with Carbimazole (CBZ). CBZ is preferable in rest of the pregnancy and postpartum period due to risk of serious liver disease with PTU. We reviewed our management of hyperthyroidism in pregnancy from 2009 to 2014. Total number of pregnancies =34, mean maternal age 32.6 years. Except one all (33/34) were diagnosed pre- pr...

Introduction: Diabetes mellitus is as a major contributor to disease severity and mortality in patients with Covid-19 infection, as the estimated increase in risk of death in hospitalised patients is 3.5-times (for T1DM) and 2.03-times (for T2DM).This retrospective analysis recruited 35 patients from three London hospitals who presented with diabetic emergencies i.e. diabetic ketoacidosis (DKA), Hyperglycaemic hyperosmolar state( HHS), presence of ketone...