Searchable abstracts of presentations at key conferences in endocrinology

ea0029p536 | Diabetes | ICEECE2012

Predictive ability of prediabetes defined by fasting plasma glucose and HbA1c for progression to diabetes in Koreans

Kim C. , Kim H. , Kim E. , Bae S. , Park J.

Background: The predictive ability of prediabetes defined by HbA1c (5.7–6.4%) or fasting plasma glucose (FPG) criteria (5.6–6.9 mmol/l) for the development of diabetes may differ according to ethnic groups, but only limited longitudinal data are available in Asians. We examined the progression rate to diabetes in Korean adults diagnosed as prediabetes according to these two criteria.Methods: We analyzed data of 9432 Korean adults (age 20–7...

ea0029p973 | Female Reproduction | ICEECE2012

Serum 25-hydroxyvitamin D and hsCRP levels in young obese women with polycystic ovary syndrome

Sung Y. , Oh J. , Lee H. , Kim D. , Baik S. , Won K. , Kim H.

Insulin resistance is one of the common features of the polycystic ovary syndrome (PCOS), and recent studies indicate the possible role of vitamin D in the pathogenesis of insulin resistance and inflammatory response. We aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D) and insulin resistance and inflammatory marker in obese women with PCOS and controls.We recruited 50 obese women with PCOS (age 25±5 years, BMI 27.5±2.3...

ea0029p1616 | Thyroid (non-cancer) | ICEECE2012

A possible common link between Graves’ disease and allergic immune response

Kim H. , Kim S. , Chae J. , Kim D. , Baek S. , Won K. , Sung Y.

Background: The elevation of serum immunoglobulin E (IgE) has been recently reported to be associated with Graves’ disease (GD). Interleukin 13 (IL-13) is a major cytokine involved in IgE synthesis and therefore may be a potential candidate gene influencing the clinical course of the GD. The aim of this study are to evaluate whether the atopic parameter such as total IgE is related to TSH receptor antibody (TRAb, thyrotropin-binding inhibitory immunoglobulin: TBII) and wh...

ea0029p1222 | Obesity | ICEECE2012

Visceral-to-subcutaneous fat ratio using fat measurement CT is essential for the assessment of risk for diabetes, hypertension and early atherosclerosis

Kim H. , Bae S. , Kim E. , Kim C.

Background and aims: Obesity is an important risk factor for metabolic and cardiovascular disease. Although body mass index (BMI) and waist circumference are convenient and economic methods for assessment of obesity, those could not fully reflect risk for diabetes, hypertension and early atherosclerosis.Materials and methods: We cross-sectionally analyzed anthropometric and laboratory data of 868 Korean adults (age 53.2±11.2 years) which were record...

ea0008p15 | Clinical case reports | SFE2004

Adrenal hypoplasia congenita and hypogonadotropic hypogonadism due to a novel splice site mutation in NR0B1

Saleh F , #S-H|#Kim|# , Walker AP , Bouloux PM

The NR0B1 (Nuclear Receptor Subfamily 0, group b, member 1) gene, originally called DAX1, encodes an atypical member of the nuclear receptor family. It is proposed to co-regulate other nuclear receptors, repress transcription of downstream gene targets such as steroidogenic factor 1 and play a role in testis development and spermatogenesis. The gene has two exons of 1,168 and 345bp, separated by a 3,385bp intron. It is expressed in the hypothalamic-pitutary-adrenal/gonadal axi...

ea0029p932 | Female Reproduction | ICEECE2012

Metabolic characteristics in women with polycystic ovary syndrome by phenotypes based on various diagnostic criteria

Sung Y. , Kim D. , Baik S. , Won K. , Kim H. , Oh J. , Lee H.

The metabolic features of Polycystic ovary syndrome (PCOS) can vary based on the definition used. The aim of this study is to compare the metabolic characteristics of PCOS according to the phenotypes from various diagnostic criteria and help to establish a optimal diagnostic criteria.Subjects with PCOS defined by the NIH criteria (n=494) and the Rotterdam criteria (n=568) and regular cycling non-hirsuite control women (n=1000) were r...

ea0009p148 | Thyroid | BES2005

Gene regulation by the c-terminal pxxp motif of pituitary tumor transforming gene (PTTG)

Gokce C , Tannahill L , Stratford A , Khanim F , Pemberton H , Kim D , Gittoes N , Boelaert K , Franklyn J , McCabe C

PTTG is tumourigenic in vivo and transactivates fibroblast growth factor-2 (FGF-2). We have previously identified expression of PTTG and FGF-2 as potential prognostic indicators for differentiated thyroid cancer. Critical to PTTG function is a double PXXP motif, forming a putative SH3-interacting domain. We employed cDNA array approaches to identify further genes regulated via this region. MCF12A cells were transiently transfected with vector-only (VO) control, wild-type (WT)-...

ea0007oc10 | Development and growth | BES2004

Key mitotic regulators securin and separase in the human fetal brain

Boelaert K , Pemberton H , Kim D , Tannahill L , Chan S , Khanim F , Gittoes N , Franklyn J , Kilby M , McCabe C

Human securin, also known as pituitary tumor transforming gene, plays a critical role during cell division. Ubiquitination of securin during the metaphase to anaphase transition releases its binding partner separase, which cleaves the cohesins holding sister chromatids together. We recently demonstrated reduced securin expression in human fetal versus adult brain, and dissected its role in affecting the proliferation of human embryonal CNS precursor NTERA-2 (NT-2) cells. We ha...

ea0029p279 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Gastrectomy for early gastric cancer is associated with decreased cardiovascular mortality in accordance with amelioration of metabolic abnormalities, visceral adiposity and atherosclerosis

Lee Y. , Han S. , Kim H. , Hyung W. , Lim J. , Lee K. , Lee H. Lee E. , Kang E. , Ahn C. , Cha B. , Lee H.

Objectives: We investigated cardiovascular and all-cause mortality in patients who underwent gastrectomies for early gastric cancer (EGC), and analyzed the changes in metabolic parameters in these patients after surgery.Background: Bariatric surgery, including gastric banding and gastric bypass, effectively induces weight loss and resolves cardiovascular comorbidities in obese patients.Methods: 2477 patients who underwent gastrecto...

ea0029p504 | Diabetes | ICEECE2012

Glycoalbumin is the best indicator for glycemic variability assessed by continuous glucose monitoring

Suh S. , Joung J. , Park S. , Cho Y. , Jin S. , Kim S. , Kim H. , Bae J. , Kim S. , Chung J. , Min Y. , Lee M. , Lee M. , Kim K. , Kim J.

Aims: We investigated the interrelationship between HbA1c, fructosamine, glycoalbumin (GA), 1,5-anhydroglucitol (1,5-AG) with glycemic variability data from continuous glucose monitoring system (CGMS).Methods: Seventy diabetic patients (mean age of 54 years including seven type 1 diabetes mellitus subjects) were enrolled, and all wore a CGMS for 72 hours. For the parameters of glucose excursion, mean glucose, standard deviation (SD) of glucose, the area ...