Searchable abstracts of presentations at key conferences in endocrinology

ea0016oc3.8 | Diabetes and obesity | ECE2008

Plasma endothelin as a biochemical marker of endothelial dysfunction in endocrine diseases with increased cardiovascular risk

Kirilov Georgi

Background: The aim of the present study was to represent our summarized results of plasma endothelin-1 (ET-1) level determined in some endocrine diseases like diabetes, hyper- and hypothyroidism, Cushing’s disease, acromegaly and male hypogonadism in which the existence of endothelial dysfunction and increased cardiovascular risk is proved.Patients and results: In patients with type 2 diabetes (n=34), plasma ET-1 (0.9±0.17 pmol/l) corre...

ea0014p577 | (1) | ECE2007

Midnight salivary cortisol vs. urinary free cortisol for the diagnosis of Cushing’s syndrome

Yaneva Maria , Kirilov Georgi , Zacharieva Sabina

Introduction: Midnight salivary cortisol measurement (MSC) has been recently introduced as a diagnostic test for hypercortisolism. The aim of our study was to compare the diagnostic value of two methods of screening for Cushnig’s syndrome (CS): MSC and 24-h urinary free cortisol (UFC), wildely accepted as a ‘gold standard’ for this diagnosis.Patients and methods: Three groups were studied: 30 patients with CS (mean age±S.D.</sm...

ea0041ep432 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Predictive value of risk factors for the progression from prediabetes to type 2 diabetes

Tankova Tsvetalina , Chakarova Nevena , Dakovska Lilya , Atanassova Iliana , Kirilov Georgi

Background: Diabetes and prediabetes have become major public health problems in recent decades.Objectives: The aim of the study was to evaluate the predictive value of risk factors on progression from prediabetes to type 2 diabetes.Materials and methods: A total of 383 subjects (213 females, 170 males), mean age 51.93±13.47 years and mean BMI 29.11±5.3 kg/m2, divided in three groups – 147 with normal gluc...

ea0041ep879 | Pituitary - Clinical | ECE2016

Does vitamin D status correlate with cardiometabolic risk factors in adults with growth hormone deficiency?

Uzunova Ivayla , Kirilov Georgi , Zacharieva Sabina , Zlatareva Naydenka , Kalinov Krassimir

Introduction: Apart from being individually associated with cardiometabolic health, Vitamin D and growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis are reported to interplay, with a positive correlation between IGF-1 and 25-hydroxyvitamin D (25(OH)D). These findings raise questions about the role of vitamin D for the adverse cardiovascular (CV) risk profile in hyposomatotropism. Thus, the aim of our study was to investigate the association between 25(OH)D and metabol...

ea0041ep908 | Pituitary - Clinical | ECE2016

Vitamin D status of adults with growth hormone deficiency

Uzunova Ivayla , Kirilov Georgi , Zacharieva Sabina , Kalinov Krassimir

Introduction: Vitamin D and growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis are reported to interplay at both endocrine and paracrine levels, with a positive correlation between IGF-1 and 25-hydroxyvitamin D (25(OH)D) in healthy subjects. Hyposomatotropism is among the conditions predisposing to lower vitamin D status due to several direct and indirect mechanisms. Thus, the aim of our study was to evaluate vitamin D status in a representative sample of adults with ...

ea0016p520 | Obesity | ECE2008

Changes of the testosterone levels in young males with obesity and metabolic syndrome

Robeva Ralitza , Kirilov Georgi , Tomova Analia , Kumanov Philip

Aim: The present study aimed to compare the androgen levels in men with obesity, metabolic syndrome /MS/ and healthy normal – weight controls.Materials and methods: Eighty-six males (mean age 29.65±8.57 /18–50/) were investigated. 31 of them were healthy (mean BMI – 23.66±1.97); 22 were with simple obesity (mean BMI – 32.79±7.16) and 33 (mean BMI – 35.78±8.71) were with overt metabolic syndrome /MS/ according ...

ea0016p617 | Reproduction | ECE2008

Anti-Mullerian hormone levels in women with polycystic ovary syndrome before and after metformin therapy

Tomova Analia , Robeva Ralitza , Kumanov Philip , Kirilov Georgi , Mechandjiev Zvetozar

Recently was established, that in the ovary Anti-Müllerian hormone (AMH) is produced by the granulose cells and correlated with the count of small antral follicles. As AMH is largely expressed throughout folliculogenesis, it is considered that the serum levels of AMH may represent both the quantity and quality of the ovarian follicle pool. To determine the changes of AMH in women with polycystic ovary syndrome (PCOS) we have studied 22 patients with this disorder and comp...

ea0014p169 | (1) | ECE2007

Prevalence of primary aldosteronism among hypertensive patients (preliminary results)

Matrozova Joanna , Zacharieva Sabina , Kirilov Georgi , Boyanov Mihail , Hristov Vladimir

Until recently primary aldosteronism /PA/ was thought to be rare, accounting for no more than 0.05–2% of the hypertensive patients. Studies published in the last decade demonstrate that primary hyperaldosteronism is a much more common cause of secondary hypertension than was previously thought, accounting for as many as 5% to 25% of hypertensives in some series. For the present, there are no data concerning the prevalence of PA in Bulgaria which determined the realization...

ea0073aep663 | Thyroid | ECE2021

Thyroid-receptor antibodies, immunoglubulin E and antinuclear antibodies in patients with Graves’ disease and their association with Graves’ orbitopathy and smoking habits

Stoynova Mariya , Shinkov Alexander , Kirilov Georgi , Kovatcheva Roussanka

IntroductionThyrotropin-receptor antibodies (TRAb) play a key role in the pathogenesis of Graves’ disease (GD) and Graves’ orbitopathy (GO) and are important for the diagnosis of both diseases. Elevated levels of immunoglobulin E (IgE) and antinuclear antibodies (ANA) were also found in GD patients. Smoking is a risk factor for GD and GO development and GO progression. We aimed to assess the associations between TRAb, IgE and ANA, and the prese...

ea0041ep498 | Diabetes complications | ECE2016

Markers of endothelial and autonomic dysfunction in early stages of glucose intolerance and in metabolic syndrome

Dimova Rumyana , Tankova Tsvetalina , Kirilov Georgi , Chakarova Nevena , Dakovska Lilia , Grozeva Greta

Aim: The aim of the study was to evaluate sE-selectin and Endothelin-1 as markers of endothelial function and autonomic tone at early stages of impaired glucose tolerance and in metabolic syndrome (MetS).Material and methods: A total of 87 subjects - 48 females and 39 males (mean age 45.7±11.6 years, mean BMI 31.4±6.6 kg/m2), divided into three groups according to glucose tolerance: 35 with normal glucose tolerance (NGT), 35 with pre...