Searchable abstracts of presentations at key conferences in endocrinology

ea0002p78 | Reproduction | SFE2001

Alternative splicing of 15-hydroxyprostaglandin dehydrogenase (PGDH) in human chorio-decidua, placenta and myometrium

Slater D , Kirk R , Bennett P

Prostaglandins are strongly implicated in the onset and maintenance of human parturition and their synthesis is increased within the uterus in association with labour. Enzymes involved in their synthesis, (cyclo-oxygenase-2), and catabolism, (prostaglandin dehydrogenase) are up and down-regulated respectively, in association with labour. The human prostaglandin dehydrogenase (PGDH) gene is approximately 34kb in size. A large 5' promoter region containing numerous potential tra...

ea0007oc28 | Endocrine tumours | BES2004

Biochemical and genetic screening in isolated and familial MEN1

Lee S , Roper E , Kirk R , Howie H , Doane A , Quarrell O , Harrison B , Ross R

Background: Multiple endocrine neoplasia type 1 (MEN1) is an inherited cancer syndrome characterized by the development of tumours in at least two of the following three main sites: parathyroid, pituitary and endocrine pancreas. Hyperparathyroidism is the most common presenting feature, with a typical age at onset of 20-25 years, and > 90% penetrance by 40 years. After extended family studies, an index case may have no affected relatives and be apparently 'isolated'. We rep...