Searchable abstracts of presentations at key conferences in endocrinology

ea0063p306 | Reproductive Endocrinology 1 | ECE2019

A rare cause of the hypergonadotropic hypogonadism: GAPO sydrome

Guclu Metin , Gorukmez Ozlem , Gorukmez Orhan , Calışkan Yasemin , Kiyici Sinem , Kisakol Gurcan

GAPO syndrome (OMIM 230740) is a rare, multiple congenital anomalies syndrome characterized by Growth retardation, Alopecia, Pseudoanodontia and Ocular manifestations. Syndrome caused by anthrax toxin receptor 1 (ANTXR1) gene (NM_032208.2) mutation leading to deficiency of an enzyme involved in the metabolism and breakdown of extracellular matrix (ECM). Disease show parental consanguinity, autosomal recessive inheritance and since first description in 1947 a total of 38 patien...

ea0037ep452 | Diabetes (complications & therapy) | ECE2015

The effect of exenatide treatment on serum ghrelin levels in patients with type 2 diabetes

Topyildiz Figen , Kiyici Sinem , Gul Zulfiye , Sigirli Deniz , Guclu Metin , Kisakol Gurcan , Cavun Sinan

Aim: Ghrelin plays an important role in stimulation of food intake and long-term regulation of body weight. In present study we aimed to investigate the effect of exenatide treatment on serum ghrelin levels in patients with type 2 diabetes.Methods: Fourteen women patients with type 2 diabetes treated with metformin and exenatide were enrolled in the study. A mixed meal test was applied to the patients while they were using their daily medications. Serum ...

ea0037ep1062 | Thyroid (non-cancer) | ECE2015

Serum prolactin and macroprolactin levels in pregnancy and association with thyroid dysfunction and thyroid autoimmunity

Guclu Metin , Cander Soner , Kiyici Sinem , Vatansever Ebru , Hacihasanoglu Arif Bayram , Kisakol Gurcan

Aim: To assess the contribution of macroprolactin (macroPRL) to high serum prolactin (PRL) levels and association of prolactin and macroprolactin levels with thyroid status and thyroid autoimmunity during pregnancy.Methods: Pregnant women (n=138) who had undergone a thyroid-stimulating hormone (TSH) screening during the first trimester of pregnancy enrolled in the study. Serum prolactin, macroprolactin, TSH, FT4, FT3, and thyroid autoantibodies ...

ea0056p417 | Diabetes complications | ECE2018

Thiol-disulfide homeostasis, total antioxidant capacity and advanced oxidant protein products in patients with diabetic peripheral neuropathy

Eroglu Derya Ustun , Kiyici Sinem , Ustundag Yasemin , Sigirli Deniz , Pekel Nilufer Buyukkoyuncu , Emlek Gamze , Kisakol Gurcan

Aim: In our study, we aimed to evaluate the relationship between oxidative stress markers such as total antioxidant capacity (TAC), advanced oxidant protein products (AOPP) and thiol-disulfide homeostasis parameters and diabetic peripheral neuropathy (PNP), an important microvascular complication of diabetes mellitus (DM).Material and methods: 80 (male/female=34/46) patients with type 2 DM and 19 healthy controls were included in the stu...

ea0056p557 | Obesity | ECE2018

Effect of surgical weight loss on the inflammatory hematological parameters in short term

Nemli Hilal , Kisakol Gurcan , Devrim Kucuksarac Kiyici Sinem , Guclu Metin , Koca Nizameddin

Introduction: In obesity, MPV is found higher compared to healthy controls. It was found that the level of NLR was predictive of the development of type 2 diabetes with high sensitivity and specificity in morbid obese patients. PLR is a new biological indicator that can assess the presence and severity of inflammation. However, in obese patients PLR was not found to associate with degree of of obesity or ratio of weight loss. Regarding the platelet count (PC) in obesity, confl...

ea0056p423 | Diabetes complications | ECE2018

Relationship between serum levels of HDL cholesterol subclasses and carotid intima media thickness in patients with type 1 diabetes mellitus

Emlek Gamze , Kiyici Sinem , Ustundag Yasemin , Sigirli Deniz , Ozhan Erhan , Eroglu Derya Ustun , Guclu Metin , Kisakol Gurcan

Aim: We aimed to investigate the possible relationship between HDL cholesterol subclasses and carotid intima media thickness (CIMT) in patients with type 1 diabetes mellitus (DM).Material and methods: Sixty-two (female/male: 33/29, mean age: 33.3±8.5 years) patients with type 1 DM at least 5 years and 20 (female/male: 10/10, mean age: 30.4±5.6 years) healthy controls were included in the study. After physical examination and anthropometric meas...