Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep322 | Clinical case reports - Thyroid/Others | ECE2017

Familial hypocalciuric hypercalcemia with a new heterozygous missense mutation of CaSR gene and cinacalcet treatment

Kiyici Sinem , Uygun Burcin , Gorukmez Orhan

Introduction: Familial hypocalciuric hypercalcemia (FHH) is an autosomal-dominant genetic disease caused by an inactivating mutation in the gene encoding the calcium sensing receptor (CaSR). The loss of function leads to increased circulating level of PTH and subsequent hypercalcemia.Case report: 20-year-old male patient referred to our center with hypercalcemia which was found after the syncope. His serum calcium level was 11.7 mg/dl and the phosphorus ...

ea0056p814 | Pituitary - Clinical | ECE2018

Pituitary enlargement due to the autoimmune thyroiditis mimicking a pituitary macroadenoma

Kiyici Sinem , Onlen Esen , Guclu Metin

Introduction: Pituitary tumorous hyperplasia with hyperprolactinemia has been described as a rare presentation of primary hypothyroidism. The loss of thyroxin feedback inhibition in primary hypothyroidism causes overproduction of thyrotropin-releasing-hormone (TRH), which results in secondary pituitary enlargement. TRH has a weak stimulatory effect on the lactotroph cells of the pituitary, so a mild to moderate increase in prolactin (PRL) levels is expected. This report descri...

ea0049gp112 | Diabetes therapy & complications 2 | ECE2017

Exenatide treatment causes suppression of serum fasting ghrelin levels in patients with type 2 diabetes Mellitus

Guclu Metin , Kiyici Sinem , Gul Zulfiye , Cavun Sinan

Aim: Ghrelin plays an important role in the stimulation of food intake and long-term regulation of body weight. In present study we investigate the long term effect of exenatide treatment on serum fasting ghrelin levels in patients with type 2 diabetes mellitus.Methods: Type 2 diabetic patients who were using metformin with and without the other oral antihiperglycemic drugs on a stable dose for at least 3 months were enrolled in the study. Body mass inde...

ea0037ep1234 | Clinical Cases–Pituitary/Adrenal | ECE2015

Hemangiopericytoma associated hypoglycaemia and concomitant secondary adrenal insufficiency

Kiyici Sinem , Topyildiz Figen , Polat Bunyamin , Hunuk Ahmet

Introduction: Hemangiopericytomas (HPC) are rare vascular tumours that may be associated with hypoglycaemia. Here we report a case of HPC with multiple metastases, accompanying severe recurrent hypoglycaemia due to the combination of different aetiologies.Case report: A 21 year-old woman was hospitalised due to loss of consciousness. The patient has been diagnosed as HPC by tibia mass biopsy 1 year ago. Tumour embolization was made several times. On admi...

ea0063p306 | Reproductive Endocrinology 1 | ECE2019

A rare cause of the hypergonadotropic hypogonadism: GAPO sydrome

Guclu Metin , Gorukmez Ozlem , Gorukmez Orhan , Calışkan Yasemin , Kiyici Sinem , Kisakol Gurcan

GAPO syndrome (OMIM 230740) is a rare, multiple congenital anomalies syndrome characterized by Growth retardation, Alopecia, Pseudoanodontia and Ocular manifestations. Syndrome caused by anthrax toxin receptor 1 (ANTXR1) gene (NM_032208.2) mutation leading to deficiency of an enzyme involved in the metabolism and breakdown of extracellular matrix (ECM). Disease show parental consanguinity, autosomal recessive inheritance and since first description in 1947 a total of 38 patien...

ea0063p616 | Diabetes, Obesity and Metabolism 2 | ECE2019

Serum total and bioactive fibroblast growth factor 21 levels are similar in patients with gestational diabetes mellitus and healthy pregnant controls

Celik Ali Osman , Kiyici Sinem , Ustundag Yasemin , Sigirli Deniz , Guclu Metin , Ustunyurt Emin

Aim: Fibroblast growth factor (FGF) 21 is a hormone which plays an important role in metabolic diseases such as diabetes, obesity and dyslipidemia. In this study; we aimed to investigate the serum total and bioactive FGF21 levels in patients with gestational diabetes mellitus (GDM) and compared with healthy pregnant controls.Material and Methods: A two-step screening method and Carpenter and Coustan criteria were used in the diagnosis of...

ea0049gp161 | Obesity | ECE2017

The association between olfaction and taste functions with serum ghrelin and leptin levels in obese women

Uygun Burcin , Kiyici Sinem , Ozmen Suay , Gul Zulfiye , Sigirli Deniz , Cavun Sinan

Aim: Olfaction and gustation have great importance on feeding behavior and food preferences. Recent published data suggests that olfaction and taste functions are modulated in response to changing levels of various molecules such as ghrelin and leptin which are play important roles on feeding and energy balance. We aimed to investigate the olfaction and taste functions in obese female patients and the association between serum ghrelin and leptin levels compared with healthy co...

ea0037ep452 | Diabetes (complications & therapy) | ECE2015

The effect of exenatide treatment on serum ghrelin levels in patients with type 2 diabetes

Topyildiz Figen , Kiyici Sinem , Gul Zulfiye , Sigirli Deniz , Guclu Metin , Kisakol Gurcan , Cavun Sinan

Aim: Ghrelin plays an important role in stimulation of food intake and long-term regulation of body weight. In present study we aimed to investigate the effect of exenatide treatment on serum ghrelin levels in patients with type 2 diabetes.Methods: Fourteen women patients with type 2 diabetes treated with metformin and exenatide were enrolled in the study. A mixed meal test was applied to the patients while they were using their daily medications. Serum ...

ea0037ep1062 | Thyroid (non-cancer) | ECE2015

Serum prolactin and macroprolactin levels in pregnancy and association with thyroid dysfunction and thyroid autoimmunity

Guclu Metin , Cander Soner , Kiyici Sinem , Vatansever Ebru , Hacihasanoglu Arif Bayram , Kisakol Gurcan

Aim: To assess the contribution of macroprolactin (macroPRL) to high serum prolactin (PRL) levels and association of prolactin and macroprolactin levels with thyroid status and thyroid autoimmunity during pregnancy.Methods: Pregnant women (n=138) who had undergone a thyroid-stimulating hormone (TSH) screening during the first trimester of pregnancy enrolled in the study. Serum prolactin, macroprolactin, TSH, FT4, FT3, and thyroid autoantibodies ...

ea0020p46 | Adrenal | ECE2009

Insulin hypoglycemia test in the diagnosis of subclinical Cushing’s syndrome

Yener Ozturk Feyza , Erturk Erdinc , Guclu Metin , Kiyici Sinem , Unal Oguzkaan , Imamoglu Sazi

Although subclinical CushingÂ’s syndrome (SCS) is an important metabolic risk factor in patients with adrenal incidentaloma, the diagnostic criteria for SCS has not been established yet. The aim of this study was to evaluate the diagnostic measures of SCS and to investigate the availability of insülin hypoglycemia test (IHT) in the diagnosis of SCS. Twenty patients with adrenal incidentaloma CT characteristics highly suggestive of benign adrenal adenoma with no overt ...