ea0049gp107 | Diabetes therapy & complications 2 | ECE2017
Schweighofer Natascha
, Genser Bernd
, Marz Winfried
, Kleber Marcus E
, Pieber Thomas R
, Obermayer-Pietsch Barbara
Aim: Increased cardiovascular incidents and a high risk for microvascular complications are associated with type 2 diabetes. Worldwide, metformin is the most commonly prescribed antidiabetic drug. Polymorphisms in the Oct1 gene can alter the function or activity of organic cation transporter 1 (Oct1), thus changing metformin efficacy (Oct1 acting as its main transporter) as well as influencing the actions of Oct1 physiological substrates. In the past, polymorphisms in...