ea0081p369 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022
Kleiman Doron
, Arad Yhara
, Permyakova Anna
, Tam Joseph
, Ben-Haroush Schyr Rachel
, Ben-Zvi Danny
Somatostatin is a hormone and neuropeptide expressed in the pancreas, gastrointestinal tract, hypothalamus, and other tissues. It regulates directly the secretion of insulin, glucagon, many of the gastrointestinal hormones, and growth hormone. It is therefore surprising the somatostatin knockout (sst-ko) mice have a very mild phenotype. We subjected sst-ko mice and heterozygous siblings which served as controls to a high-calorie diet, and confirmed that sst-ko mice gain weight...