Searchable abstracts of presentations at key conferences in endocrinology

ea0035p611 | Endocrine tumours and neoplasia | ECE2014

TSH suppressive therapy accelerates progression of sacropenia in post-menopausal women

Diedhiou Demba , Klein Marc , Weryha Georges , Feigerlova Eva

Background: TSH-suppressive therapy in patients with differentiated thyroid carcinoma (DTC) leads to iatrogenic thyrotoxicosis and may be associated with alterations in body composition and bone mineral density (BMD). Its effects on a sarcopenia in elderly have not been in detail investigated.Objective: The objective was to compare changes in total and areal lean body mass (LBM), body fat mass (BFM) and BMD in postmenopausal female patients with DTC duri...

ea0070aep685 | Pituitary and Neuroendocrinology | ECE2020

High prevalence of pituitary deficiency after cranial radiation therapy for skull base meningioma: The importance of an annual screening.

Raymond Perrine , Cuny Thomas , Klein Marc , Bernier-Chastagner Valerie

Purpose: To determine the risk of developing hypopituitarism after cranial irradiation for skull base meningiomas. Cranial irradiation is often chosen as first treatment in skull base meningiomas to avoid risk to proximally-located critical structures. While cranial irradiation has been associated with high risk of inducing hypopituitarism, few studies concern meningiomas.Methods and materials: Fifty-two adult patients receiving photon-beam therapyfor sk...

ea0073aep580 | Reproductive and Developmental Endocrinology | ECE2021

Adverse effects of gender affirming hormonal therapy in transgender persons: assessing reports in the French pharmacovigilance database

Yelehe Melissa , Klein Marc , Gillet Pierre , Maurier Anais , Feigerlova Eva

BackgroundOnly limited data are available regarding adverse effects of gender affirming hormonal treatment (HT) mainly due to the lack of population-based studies with adequate controls, thus making spontaneous reporting systems a valuable tool to detect potential side reactions.ObjectiveIn this nationwide retrospective study, we aimed to analyse adverse drug reactions (ADRs) in relation to gender affirming H...

ea0063p1150 | Reproductive Endocrinology 2 | ECE2019

Evolution of referrals for gender dysphoria and trends in the sex ratio: Data from the Trans’Est Gender Identity Centre of the University Hospital of Nancy (2002–2018)

Feigerlova Eva , Pascal Veronique , Ganne-Devonec Marie-Odile , Consolandi Pierre , Klein Marc , Guerci Bruno

Background: During the last decennium, an increase in the number of persons referred to gender identity centres has been observed. Epidemiological data have not yet been formally studied in France. Here we report the experience from the TransÂ’Est Gender Identity Centre of the University Hospital of Nancy.Aim: To study the number of people seeking transgender care, the age at referral and the trends in the sex ratio.Methods: Th...

ea0070aep814 | Reproductive and Developmental Endocrinology | ECE2020

Early impact of cross-sex steroids on body composition and metabolic profile in young transgender subjects

Consolandi Pierre , Pascal Veronique , Samhani Caroline , Larose Clement , Bohme Philip , Marc Klein , Ziegler Olivier , Feigerlova Eva

Background: In females transitioning to males (FtM) and in males transitioning to females (MtF), exogenous cross-sex steroids are prescribed to favour development of secondary characteristics of desired sex, while endogenous hormone production is inhibited.Aims and design: To study early impact of cross-sex steroids on body composition, metabolic profile and pro-inflammatory parameters in young transgender persons before and after 12 months of gender-aff...

ea0090p398 | Endocrine-related Cancer | ECE2023

Severe insulin secretion by an inoperable metastatic insulinoma can be controlled by 177-Lu-DOTA-TATE radionuclide therapy: a case report

Riley George , Creton Cecile , Demarquet Lea , Raymond Perrine , Chevalier Elodie , Lambert Aurelien , Guerci Bruno , Klein Marc , Scheyer Nicolas

Introduction: Metastatic insulinoma is an extremely rare form of malignant insulinoma involving metastatic growth where classical surgical treatment is often impossible. Medical therapies are widely considered and reserved for those especially with inoperable insulinoma with the goals of reducing tumor size, but also of reducing hypoglycemic events either by acting directly on the insulinoma cells (reducing excess insulin secretion from the insulinoma cells or reducing tumor v...

ea0081oc6.3 | Oral Communications 6: Endocrine-Related Cancer | ECE2022

Systematic detection of mosaicism by using digital NGS in a cohort of 119 unresolved MEN1 cases reveals 3 new MEN1 mosaicisms

Lagarde Arnaud , Mougel Gregory , Coppin Lucie , Haissaguerre Magalie , Le Collen Lauriane , Klein Marc , Odou Marie-Francoise , Tabarin Antoine , Brixi Hedia , Delemer Brigitte , Barlier Anne , Romanet Pauline

Context: Mosaicism is a feature of several inherited tumor syndromes but is rarely systematically looked for in routine. MEN1 is an autosomal dominant hereditary syndrome characterized by several endocrine tumors affecting parathyroids, pancreas, and anterior pituitary most of the time, due to inactivating mutations in the MEN1 gene. Few cases of mosaicism in Multiple Endocrine Neoplasia type 1 (MEN1) have been described. MEN1 mosaicism is probably under-diag...