Endocrine Abstracts

Graves’ disease (GD) is an autoimmune disease that can affect other tissues in addition to the thyroid gland. Depending on the intensity of the immune response, in addition to hyperthyroidism, orbitopathy, dermatopathy and acropachy can also occur. Extrathyroidal manifestations of GD are most often the result of a more pronounced immune response. Thyroid dermatopathy (TD) is a rare extrathyroidal manifestation of GD, almost always associated with Graves’ orbitopathy ...

Introduction: Graves orbitopathy (GO) is the most common extrathyroidal manifestation of autoimmune hyperthyroidism, although it can rarely occur in euthyroid and hypothyroid patients with chronic autoimmune thyroiditis. The eye involvement in GO is frequently bilateral and symmetric. When atypical ocular or incongruent biochemical findings occur, conditions that may mimic GO should be excluded. Immunoglobulin G4 - related disease (IgG4-RD) is a rare, progressive immune-mediat...

Background: Pseudohypoparathyroidism (PHP) is a genetic disorder characterized by resistance or an inappropriate response in specific G protein receptors. The pathophysiology of PHP type 1-a involves an autosomal dominant mutation of the GNAS complex locus. A classic triad of abnormality includes hypocalcemia, hyperphosphatemia, and elevated parathyroid hormone (PTH) concentrations. Additionally, other hormonal imbalances can occur in PHP and higher calcitonin levels have been...

Background: Thyroid hormones have regulatory effect on serotonin and noradrenaline and thyroid dysfunction is closely linked to some mental disorders. Besides depression and anxiety, and increased risk for suicide is demonstrated in patients with Graves’ disease (GD).The aim: of our research was to determine the symptomatology of depression in patients with hyperthyroidism and Graves’ orbitopathy (GO) and compare it with hyperthyroid patients w...

Serum calcitonin (CT) screening of thyroid nodules is a highly sensitive test for early diagnosis of medullary thyroid carcinoma (MTC) and is used for initial diagnosis and post-surgical follow-up. MTC is neuroendocrine tumor derived from parafollicular C cells which produce calcitonin. It is a rare tumor, accounting for 5-10% of all thyroid carcinomas, with a favorable prognosis if diagnosed early. A 74-year-old patient was referred to our clinic due to elevated basal CT leve...