Searchable abstracts of presentations at key conferences in endocrinology

ea0035p690 | Male reproduction | ECE2014

The variant FSHB −211G>T attenuates serum FSH levels in the supraphysiological gonadotropin setting of Klinefelter syndrome

Gromoll Joerg , Busch Alexander , Zitzmann Michael , Kliesch Sabine , Tuettelmann Frank

Background: Klinefelter syndrome (KS) is the most frequent genetic cause of male infertility. Individuals share the endocrine hallmark of hypergonadotropic hypogonadism, displaying high gonadotropin levels due to deficient testicular function. A single-nucleotide polymorphism (SNP) located within the FSHB promoter region (−211G>T, rs10835638) was recently shown to be associated with reduced serum FSH levels and other reproductive parameters in men. The objec...

ea0032oc5.4 | Reproduction | ECE2013

Influence of variants in the FSHB and FSHR gene on reproductive parameters in males and females

Gromoll Joerg , Schuring Andreas , Busch Alexander , Kliesch Sabine , Tuttelmann Frank

Background: Recently, a single nucleotide polymorphism (SNP) in the FSHB promoter (−211G>T, rs10835638) was found to be associated with lower serum FSH levels and oligozoospermia in males. In contrast, a SNP in the FSH-receptor gene (FSHR, 2039A>G, rs6166) was previously shown to be associated with FSH levels in women only.Subjects and methods: One thousand two hundred and thirteen male partners in infertile couples without known c...

ea0063gp68 | Reproductive Axis | ECE2019

DHT, rather than free testosterone, influences symptoms of aging in eugonadal men

Sansone Andrea , Kliesch Sabine , Tuttelmann Frank , Dugas Martin , Isidori Andrea M. , Schlatt Stefan , Zitzmann Michael

Aim: To assess the relation between questionnaires of androgenic function (AMS and IIEF-EF scores) and sex hormones (DHT, estradiol and total and free testosterone) in men attending an outpatient clinic for endocrine and reproductive disorders.Methods: We retrospectively reviewed all data entered in the electronic database of the Münster Center of Reproductive Medicine and Andrology (CeRA) Androbase from patients visited between January 2015 and Oct...

ea0070aep802 | Reproductive and Developmental Endocrinology | ECE2020

Pituitary response to GnRH stimulation in patients with secondary hypogonadism is modulated by different FSHB -211 G/T genotypes

Sansone Andrea , Schubert Maria , Tüttelmann Frank , Zitzmann Michael , Krallmann Claudia , Kliesch Sabine , Gromoll Jörg

Background: The FSHB –211 G > T single nucleotide polymorphism (SNP) is known to affect pituitary FSH output by reducing the transcriptional activity of FSHB. Identifying the response of the pituitary to exogenous GnRH stimulation in subjects with FSHB -211 G > T SNP could provide useful information concerning the mechanisms regulating FSH synthesis and release.Objectives: This study aimed to assess the pituitary...