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ea0063p726 | Pituitary and Neuroendocrinology 2 | ECE2019

Detection of pituitary adenoma specific circulating tumour DNA using semiconductor sequencing

Pečulis Raitis , Megnis Kaspars , Rovīte Vita , Laksa Pola , Niedra Helvijs , Balcere Inga , Nazarovs Jurijs , Stukēns Jānis , Konrāde Ilze , Pīrāgs Valdis , Klovinš Jānis

Objective: The most common type of pituitary diseases are pituitary adenomas (PA) of different origin. Although non-metastasizing, they still cause increased mortality and morbidity. Clinically significant PAs affect around 0.1% of population during lifetime. Circulating cell free DNA (ccfDNA) is approximately 165 bp long DNA fragments which are released in bloodstream upon cell death. ccfDNA has been used to investigate presence and properties of various cancers. Data on ccfD...