ea0041oc6.4 | Diabetes therapy & complications | ECE2016
Wolf-van Buerck Lelia
, Schuster Marion
, Baehr Andrea
, Klymiuk Nik
, Wolf Eckhard
, Seissler Jochen
Transplantation of pancreas or isolated Langerhans islets can cure type 1 diabetes. Xenografts from transgenic pigs represent a promising source to overcome the shortage of organ donors. We investigated the immunosuppressive effect of local LEA29Y expression (a high-affinity variant of CTLA4-Ig) by transplantation of neonatal porcine islet-like clusters (NPICCs) from INSLEA29Y transgenic pigs into humanized mice. NPICCs from 15 day-old pigs expressing LEA29Y und...