Searchable abstracts of presentations at key conferences in endocrinology

ea0014p224 | (1) | ECE2007

Effects of PGC-1α on endothelial function and apoptosis

Park Joong-Yeol , Won Jong Chul , Lee Ki-Up , Lee Woo Je , Ko Kyung Soo , Song Kee-Ho , Lee In-Kyu

Aims: Central obesity is associated with increased cardiovascular morbidity and mortality. It has been proposed that increased lipid accumulation in vascular tissue and the consequent increase in oxidative stress may be a missing link between obesity and atherosclerosis. The peroxisome proliferators-activated receptor (PPAR)-γ coactivator 1-α (PGC-1α) is a transcriptional coactivator playing an important role in energy metabolism. PGC-1α is present in vascu...