Searchable abstracts of presentations at key conferences in endocrinology

ea0081ap5.1 | European Hormone Medal Award Lecture | ECE2022

Great impact in low quantities - thyroid hormones, trace elements and endocrine disruptors

Kohrle Josef

Thyroid hormones (TH) regulate (brain) development, growth, body temperature, most pathways involved in energy and structural metabolism as well as anabolic and catabolic reactions. Inadequate availability of essential trace elements (iodine, selenium, iron, zinc) limits TH biosynthesis, metabolism and action. Endocrine-disrupting chemicals (EDC), i.e., exogenous chemicals or their mixtures, can interfere with any aspect of TH synthesis, distribution, transport, metabolism, an...

ea0020s24.3 | Environmental pollutants as endocrine disruptors | ECE2009

Endocrine disruptors or goitrogens? Effects of UV screens, synthetic and nutritive compounds on thyroid function

Kohrle Josef

Thyroid hormone (TH) biosynthesis, storage and secretion is organized in a complex series of biochemical reactions round an evolutionary conserved functional unit, the thyroid follicle, a highly vascularised epithelial structure enclosing the colloidal lumen mainly composed of thyroglobulin (Tg). The luminal apical surface of this tight epithelial monolayer is the site of H2O2 dependent TH biosynthesis and is involved in mobilization of Tg, the colloidal ...

ea0041oc2.1 | Receptors & Signalling | ECE2016

3-T1AM signaling in the rat thyrocyte cell line PCCL3

Schanze Nancy , Khajavi Noushafarin , Mergler Stefan , Biebermann Heike , Kohrle Josef

The endogenous decarboxylated thyroid hormone (TH) metabolite 3-Iodothyronamine (3-T1AM) exerts partially TH antagonistic effects in rodents and was shown to suppress the hypothalamic pituitary thyroid axis in rats after single dose application. Therefore, it might play a role in maintaining TH homoeostasis. Among the molecular targets of 3-T1AM are G protein-coupled receptors like the trace amine associated receptor 1 (TAAR1) and adrenergic receptors. Furthermore, 3-T1AM was ...

ea0037oc6.1 | Thyroid | ECE2015

3,5-T2 might play a crucial role in the rodent heart

Lietzow Julika , Dhandapani Priyavathi , Jonas Wenke , Kohrle Josef

The endogenous thyroid hormone metabolite 3,5-diiodothyronine (3,5-T2) has attracted attention as a metabolically active substance modulating metabolism via classical thyroid hormone (TH) receptor-dependent and rapid plasma membrane, cytosolic and mitochondrial signaling pathways. Accordingly, 3,5-T2 has been proposed as a potential hypolipidaemic agent without inducing thyromimetic effects and is frequently used as illicit weight-reducing agent. The objective of the present s...

ea0020oc5.1 | Thyroid: Basic and Clinical | ECE2009

Neurological and behavioral phenotypes in mice lacking Mct8-mediated neuronal T3 uptake

Schweizer Ulrich , Wirth Eva , Roth Stephan , Kohrle Josef , Gruters Annette

Thyroid hormone transport into cells critically depends on plasma membrane transport proteins. One of these, monocarboxylate transporter 8 (MCT8), is mutated in patients suffering from a form of X-linked mental retardation, the Allan-Herndon-Dudley syndrome. These patients are characterized by abnormal thyroid hormone and TSH plasma levels indicating a role for MCT8 in the regulation of the thyroid hormone axis. Mice lacking the Mct8 gene replicate the thyroid hormone a...

ea0020oc5.2 | Thyroid: Basic and Clinical | ECE2009

Selenium and iodine determination from single murine thyroid lobes by TXRF-spectroscopy

Renko Kostja , Behrends Thomas , Stosnach Hagen , Kohrle Josef , Schomburg Lutz

Iodine (I) and selenium (Se) are two essential trace elements for regular thyroid gland functioning and thyroid hormone metabolism. Most Europeans are only marginally supplied with both elements through their daily nutrition. The mammalian organism has developed efficient and highly complex mechanisms to control I and Se uptake, metabolism and recycling. The thyroid gland is equipped with the necessary transporters and metabolizing enzymes for I uptake and bioconversion into t...

ea0016p221 | Diabetes and cardiovascular diseases | ECE2008

SelS/Tanis controls insulin sensitivity and is regulated by acute phase and diet

Stoedter Mette , Renko Kostja , Kohrle Josef , Schomburg Lutz

Background: Selenoproteins contain the 21st proteinogenic amino acid selenocysteine (Sec) and exert important biological functions. Selenoprotein S (SelS) has only recently been identified and appears to be implicated in type 2 diabetes and inflammation. In vitro studies have shown that SelS expression is controlled by circulating cytokine and glucose levels. Mechanistically, SelS participates in the retro-translocation during quality control in the ER and the ER-associ...

ea0056gp254 | Thyroid non cancer | ECE2018

Proteome analysis of 3,5-T2-treated primary mouse hepatocytes

Golchert Janine , Lietzow Julika , Volker Uwe , Homuth Georg , Kohrle Josef

Introduction: Besides the classical thyroid hormones T4 and T3 the endogenous thyroid hormone metabolite 3,5-diiodothyronine (3,5-T2) attracted attention during the last years due to its metabolic activity. 3,5-T2 exerts thyromimetic action on the hypothalamus-pituitary-thyroid axis and the heart as well as on energy and lipid metabolism. In previous liver transcriptome analyses of 3,5-T2-treated lean and diet-induced obese male mice, effects on hepatic lipid, steroid, xenobio...

ea0049oc3.4 | Receptors & Signalling | ECE2017

Treatment with thyroid hormone metabolite 3,5-T2 alters cholesterol and sex steroid metabolism in mouse liver

Lietzow Julika , Golchert Janine , Homuth Georg , Jonas Wenke , Ohlsson Claes , Landin Andreas , Poutanen Matti , Kohrle Josef

Recent findings revealed 3,5-diiodo-L-thyronine (3,5-T2) as a metabolically active iodothyronine affecting hepatic energy and lipid metabolism. Therefore, 3,5-T2 has been proposed as a potential hypolipidemic agent for treatment of obesity and its hepatic aftermath. So far only limited data exists relating to the effects of 3,5-T2 on metabolism in euthyroid mammals maintained on high-fat diet from the day of weaning onwards. Therefore, we performed a study in wh...

ea0041gp194 | Thyroid - Basic | ECE2016

Circulating 3-T1AM and 3,5-T2 in critically ill patients: a cross-sectional observational study

Langouche Lies , Lehmphul Ina , Perre Sarah Vander , Kohrle Josef , Van den Berghe Greet

Introduction: Patients in need of an intensive care unit (ICU) treatment due to severe diseases often develop the non-thyroidal illness syndrome (NTI). These critically ill patients present with low thyroxine (T4), low 3,3’,5-triiodothyronine (T3) and elevated reverse T3 (rT3) serum concentrations while TSH and 3,3’-diiodothyronine (3,3’-T2) concentrations remain unaffected. To further elucidate the underlying changes ...