ea0020p573 | Neuroendocrinology, Pituitary and Behaviour | ECE2009
, Roth Stephan
, Schweizer Ulrich
, Kohrle Joseph
Objective: Mutations in the gene encoding the thyroid hormone transport protein, monocarboxylate transporter 8 (MCT8), underlie severe mental retardation. In vitro expression of mutant transporters was performed to understand phenotypical differences.Methods: We established cell lines stably expressing 16 MCT8 variants in JEG1 and MDCK cells. Several of these mutants have never been analysed before. The cell lines were characterized according to M...