Searchable abstracts of presentations at key conferences in endocrinology

ea0016p701 | Thyroid | ECE2008

Thyronamines are isozyme specific substrates of deiodinases

Piehl Susanne , Heberer Thomas , Balizs Gabor , Scanlan Thomas , Smits Rene , Koksch Beate , Kohrle Josef

3-iodothyronamine (3-T1AM) and thyronamine (T0AM) are novel endogenous signaling molecules that exhibit great structural similarity to thyroid hormones but apparently antagonize classical thyroid hormone (T3) actions. Their proposed biosynthesis from thyroid hormones would require decarboxylation and more or less extensive deiodination. Deiodinases (Dio1, Dio2 and Dio3) catalyze the removal of iodine from their substrates. Since a role of deiod...