Searchable abstracts of presentations at key conferences in endocrinology

ea0022p347 | Diabetes | ECE2010

Quantitative and qualitative changes in T regulatory lymphocytes (Tregs) in newly-diagnosed patients with type 1 diabetes

Paschou Stavroula , Vartholomatos George , Kolaitis Nikolaos , Papadopoulos George , Tsatsoulis Agathocles

Introduction: T regulatory lymphocytes (Tregs) are defined as CD4+CD25high T lymphocytes and are thought to regulate immune tolerance. The Foxp3 protein level in Tregs is proportional to CD25 protein surface expression and regulatory function, but inversely proportional to IL-7R (CD127) level, the receptor for the growth and survival of T cells. We investigated possible differences in Tregs between newly diagnosed type 1 diabetes (DM1) patients and contro...