Searchable abstracts of presentations at key conferences in endocrinology

ea0011p675 | Reproduction | ECE2006

Evidence for synergy of SHBG and androgen receptor genes in PCOS phenotype

Xita N , Georgiou I , Psofaki V , Kolios G , Tsatsoulis A

Polycystic ovary syndrome (PCOS) is a common endocrinopathy with hyperandrogenemia to be its strongest genetically determined characteristic. Our aim was to investigate the potential synergy of two functional polymorphisms: the (TAAAA)n polymorphism of the sex hormone-binding globulin gene (SHBG) known to be associated with PCOS and influence serum SHBG levels (longer repeats were associated with lower SHBG levels) and the (CAG)n polymorphism of androgen receptor gene (...