Endocrine Abstracts

Introduction: Generously supported by IPSEN)-->Clinically nonfunctioning pituitary adenomas (CNFPA) represent 25–50% of all pituitary lesions. They may be asymptomatic and discovered incidentally or they may be diagnosed due to visual impairment or symptoms of pituitary hormone insufficiency. There is little data on apoplexy frequency in the CNFPA.The aim of our study was to assess the frequency of CNFPA a...

Introduction: Denosumab is a new pharmacotherapy option for postmenopausal osteoporosis. It is a human monoclonal antibody against RANKL, acting as an osteoprotegerin (OPG) analog. Recently, osteoprotegerin levels were found to be elevated in type two diabetes while insulin resistance was shown to be positively associated with decreased serum OPG levels, in healthy obese subjects. However, no study has been conducted in order to clarify the effect of anti-RANKL factors adminis...

Thyroid antibodies are a heterogenous group of antibodies with diverse and partly unknown properties. The effect of these antibodies on other organ systems and especially on the renal system is unknown. There is however some evidence that thyroid, in particular thyroglobulin antibodies, may affect renal function and may cause glomerulonephritis and possibly nephrotic syndrome. Nephrotic syndrome may alter thyroxine metabolism, as it affects its renal excretion and its albumin ...

Acromegaly is a disease characterized by the presence of a pituitary ademona which secretes excessive amounts of growth hormone. The presence of an adenoma causing acromegaly in the context of multiple endocrine neoplasia syndromes has been described. However, the presence of solitary pituitary adenomas causing acromegaly in siblings is extremely rare.Aim: The aim was to describe acromegaly in 2 siblings.A male patient, aged 56 yea...