Searchable abstracts of presentations at key conferences in endocrinology

ea0032p728 | Obesity | ECE2013

Serum- and glucocorticoid-regulated kinase 1 in obesity-related adipose tissue and peripheral inflammation

Reiter Marie Helene , Kiefer Florian , Zeyda Maximilian , Kopecky Chantal , Stulnig Thomas , Luger Anton , Vila Greisa

The serum- and glucocorticoid-regulated kinase 1 (Sgk1) is a direct transcriptional target of glucocorticoids and is post-translationally activated by the insulin/IGF1 pathway. Distinct polymorphisms in the Sgk1 gene are associated with increased body weight and type 2 diabetes. Here we investigate the expression and regulation of Sgk1 in human obesity.In both omental and subcutaneous human adipose tissue, Sgk1 expression is significantly increased in 20...