Searchable abstracts of presentations at key conferences in endocrinology

ea0020p357 | Diabetes and Cardiovascular | ECE2009

Pharmacokinetics of the dipeptidyl peptidase-4 inhibitor saxagliptin in subjects with renal impairment

Boulton David , Tang Angela , Patel Chirag , Li Li , Xu Xiaohui , Frevert Ernst , Kornhauser David

Background/aims: Saxagliptin is a potent, selective dipeptidyl peptidase-4 (DPP-4) inhibitor, specifically designed for extended inhibition of the DPP-4 enzyme. Saxagliptin is cleared by both metabolism and renal excretion. The aims of this study were to determine the effect of renal impairment (RI) and haemodialysis (HD) on the pharmacokinetics of saxagliptin.Methods: This open-label, parallel-group study was conducted in subjects with normal renal func...