Searchable abstracts of presentations at key conferences in endocrinology

ea0061ou4 | Plenary 1: Can it be healthy to be overweight? Is so when? | OU2019

Can it be healthy to be overweight? If so when?

Kos Katarina

Being overweight or obese is by many people considered a lifestyle choice. It is primarily us healthcare professionals who worry about the health impact of obesity, however are we always right? Whom should we consider at risk and when should we (try) to intervene? Is there something like healthy obesity? This talk is aimed to reflect and understand what happens with adipose tissue when we gain weight, how it copes with surplus energy and how it links with obesity and its compl...

ea0019p161 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

MMIF but not MCP-1 is correlated with adipose-derived TNF alpha in human obesity

Kos Katarina , Wong Steve , Kerrigan David , Pinkney Jonathan , Wilding John

Background: Adipose-tissue (AT)-derived cytokines contribute to systemic inflammation and insulin resistance. The systemic inflammation observed in obesity is thought to be mainly derived from the stroma–vascular fraction of adipose tissue due to macrophage-infiltration of AT in obesity. Macrophages are thought to be recruited and trapped in AT by release of chemoattractant-molecules such as monocyte-chemoattractant-protein-1 (MCP-1) and macrophage-migration-inhibitory-fa...

ea0015p105 | Cytokines and growth factors | SFEBES2008

Unlike subcutaneous expression of IL-6 and IL-18, omental expression of IL-6, IL-18 and MCP-1 are not related to systemic cytokine levels in human obesity

Kos Katarina , Wong Steve , Kerrigan David , Wilding John , Pinkney Jonathan

Background and aims: Adipose tissue (AT) secretes cytokines which contribute to systemic inflammation in obesity. Cytokines like monocyte-chemoattractant-protein-1 (MCP-1) have also been associated with macrophage infiltration of AT in obese mice. However, it is unknown whether visceral-AT (VAT) or subcutaneous-AT (SCAT) expression is related to serum levels of these cytokines in humans.Methods: Morbidly-obese non-diabetic subjects undergoing bariatric s...

ea0014p222 | (1) | ECE2007

Human adipose tissue derived DPP-IV regulates lipolysis through NPY in cultured abdominal subcutaneous adipocytes

Kos Katarina , Baker Adam , Harte Alison , McTernan Philip , O’Hare Paul , Kumar Sudhesh

We have previously shown that the orexigenic hormone NPY is secreted by human adipocytes. The orexigenic hormone NPY(1–36) is truncated by the dipeptidyl-inhibitor IV (DPP-IV) to NPY(3–36) as consequence its affinity changes from receptor Y1 to Y4 and 5. The aim was to investigate whether DPP-IV is expressed in adipose tissue (AT) where it could modulate adipose tissue growth through modulation of NPY activity. This is relevant in light of DPP-IV inhibitors utilised ...

ea0013p147 | Diabetes, metabolism and cardiovascular | SFEBES2007

Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum

Kusminski Christine , Kos Katarina , Schraw Todd , O’Hare Joseph , Ahima Rexford , Scherer Philipp , Kumar Sudhesh , McTernan Philip

Aims/hypothesis: Adiponectin is an adipocyte-derived secretory factor that is highly specifically expressed in adipocytes. It exerts effects on energy homeostasis via peripheral and central mechanisms. However, it is not clear whether adiponectin is crossing the blood brain barrier in humans. In serum, adiponectin circulates in several different complexes, each of which has distinct functions. Here, we wanted to test whether adiponectin can be found in human cerebrospinal flui...

ea0013p121 | Cytokines and growth factors | SFEBES2007

The peripheral actions of the des-acyl and octanoylated ghrelin on leptin in human abdominal subcutaneous adipocytes

Goodyear Steve , Fernandez da Silva Nancy , Kos Katarina , Harte Alison , Sung Ed , Wong Ling , O’Hare Joseph , Kumar Sudhesh , Nwokolo Chuka , McTernan Philip

The anorexigenic leptin and orexigenic ghrelin, are peripheral signals that control appetite via the hypothalamic neuropeptide Y (NPY) system. Ghrelin exists in an inactive (des-acyl) and active (octanoylated) form which acts via the GHS-R1a. Whilst a great deal is understood about central interaction of these peptides their peripheral pathways remain uncertain. Adipose tissue (AT) produces several neuropeptides. Due to the importance of AT in the control of energy homeostasis...