Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep904 | Pituitary - Clinical | ECE2016

Subarachnoid haemorrhage results in poor quality of life independent of pituitary hormone concentrations

Nagras Zainab , Klose Marianne , Poulsgaard Lars , Kosteljanetz Michael , Brennum Jannick , Feldt-Rasmussen Ulla

Introduction: Subarachnoid haemorrhage (SAH) is associated with a mortality rate of 30% and the survivors face significant morbidity including fatigue, isolation, depression and sleep disorders; factors affecting general health related quality of life (QoL). QoL is also known to be decreased in pituitary-hypothalamic insufficiency and tends to improve after treatment. SAH has been suggested to be a common cause of hypopituitarism by some whereas not by others. We aimed to inve...

ea0014p23 | (1) | ECE2007

Human somatotrophic (GH) adenoma cells – interleukin (IL)-1β induces production of il-6 and il-8.

Diness Signe , Rasmussen Æse Krogh , Bendtzen Klaus , Kosteljanetz Michael , Feldt-Rasmussen Ulla

Aim: to establish a human in vitro system for the study of pituitary cells in culture and subsequently to study the influence of the pro-inflammatory cytokines interleukin (IL)-1β and tumour necrosis factor (TNF)-α on the function of the somatotrophic cells inclusive the ability of the cells to produce IL-6 and IL-8.Methods: Pituitary adenomas were obtained from hypophysectomies of patients with acromegaly. The tissue was enzymatically d...

ea0014p584 | (1) | ECE2007

Acute and long-term pituitary insufficiency in traumatic brain injury: a prospective cohort study

Klose Marianne , Kosteljanetz Michael , Poulsgaard Lars , Brennum Jannick , Juul Anders , Feldt-Rasmussen Ulla

Objective: To estimate the occurrence of hypopituitarism 12 months following traumatic brain injury (TBI), describe the time course, evaluate the predictive value of early hormonal changes and trauma related parameters, as well as out-come.Methods Forty-six patients with TBI (mild (GCS:13–15) n=22; moderate (GCS:9–13) n=9; severe (GCS<9) n=15) were included. Patients were tested early post-injury (baseline hormone level...