Searchable abstracts of presentations at key conferences in endocrinology

ea0035p1123 | Thyroid Cancer | ECE2014

Sodium–iodide symporter and its microRNA-dependent deregulation in papillary thyroid carcinoma.

Kotlarek Marta , Gierlikowski Wojciech , Kubiak Anna , Maciag Monika , Jazdzewski Krystian , Wojcicka Anna

Objectives: The sodium/iodide symporter (NIS) is a glycoprotein with unique ability of transporting iodine into the thyroid follicle. Apart from the importance in thyroid hormone synthesis, this function of NIS allows the use of radioactive iodine to target residual and metastatic thyroid cancer after thyroidectomy. However, 20–30% of thyroid tumors exhibit lowered expression of NIS, resulting in decreased uptake of radioiodine and inefficient post-surgical therapy. Mecha...

ea0035p1125 | Thyroid Cancer | ECE2014

Apical iodide transporter and its microRNA-induced silencing in thyroid malignancies

Gierlikowski Wojciech , Kotlarek Marta , Bakula-Zalewska Elwira , Jazdzewski Krystian , Wojcicka Anna

Objectives: Apical iodide transporter (AIT) is essential for thyroid homeostasis, functioning both as iodide transporter and a potent tumor suppressor. Its decreased levels observed in thyroid cancer underlie its progression and inefficiency of radioactive iodine treatment, used for ablation of post-operative and metastatic thyroid cancer cells. Mechanisms of AIT downregulation in cancer are largely unknown, but recent data on overexpression of microRNAs in thyroid cancer sugg...