Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp204 | Diabetes: Pharmacotherapy | ECE2019

Fasting insulin levels correlate with the incidence of hypoglycemic events in patients with Type 2 Diabetes treated with sulfonylureas: a retrospective cross-sectional study

Kolokas Konstantinos , Koufakis Theocharis , Avramidis Iakovos , Gerou Spyridon , Chatzidimitriou Maria , Kazakos Kyriakos , Karras Spyridon , Kotsa Kalliopi

Background: Sulfonylureas (SUs) are known to increase fasting insulin levels in patients with Type 2 Diabetes (T2D) treated with these agents. Whether this increase is related to a greater risk of hypoglycemia has not yet been sufficiently elucidated.Methods: The study included 58 patients with T2D who had been on treatment with SUs, but not insulin, for more than 2 years. Confirmed hypoglycemic episodes during the past year were self-reported by the pat...

ea0056p226 | Calcium & Vitamin D metabolism | ECE2018

Glucose metabolism in primary hyperparathyroidism: The role of parathyroidectomy

Antonopoulou Vasiliki , Grammatiki Maria , Rapti Eleni , Koufakis Theocharis , Karras Spyridon , Yavropoulou Maria , Papavramidis Theodossis , Kotsa Kalliopi

Background: Although primary hyperparathyroidism (PHPT) has been associated with diabetes mellitus (DM), the etiological link is not clear and the effect of parathyroidectomy is controversial.The aim of this observational study was to investigate the metabolic link between calciotropic hormones and glucose metabolism in PHPT patients before and after parathyroidectomy.Methods: Twenty-four consecutive patients with PHPT (Group-A) without DM were included ...

ea0073aep804 | Late Breaking | ECE2021

Effects of Christian Orthodox versus intermittent fasting on plasma irisin concentrations in overweight adults

Karras Spyridon , Koufakis Theocharis , Adamidou Lilian , Dimakopoulos Georgios , Karalazou Paraskevi , Thisiadou Katerina , Makedou Kali , Kotsa Kalliopi

Irisin is an adipomyokine produced during physical activity and implicated in the browning of adipose tissue. Existing evidence suggests an inverse relationship between irisin plasma levels and adverse metabolic outcomes; however, the exact impact of diet on irisin levels remains unclear. We aimed to assess the effects of two dietary patterns, Christian Orthodox fasting (OF) and 16:8 time-restricted eating (TRE), on irisin concentrations among overweight, metabolically healthy...

ea0090ep134 | Calcium and Bone | ECE2023

Variations in plasma free 25-hydroxyvitamin D concentrations during intermittent fasting are independently correlated with amino acid intake among meat and non-meat eaters

Karras Spyridon , Koufakis Theocharis , Adamidou Lilian , Dimakopoulos George , Melidou Eirini , Karalazou Paraskevi , Thisiadou Katerina , Zebekakis Pantelis , Makedou Kali , Kotsa Kalliopi

Background: Data on the effects of different dietary patterns on free 25-hydroxyvitamin D [25(OH)D] and vitamin D binding protein (VDBP) concentrations are scarce. Our objective was to prospectively assess changes over time in these parameters and possible correlations with diet composition among overweight adults who followed a pescatarian Orthodox intermittent fasting (OF) regimen and controls who followed a low-fat 12:12 diet for 7 weeks.Methods: Tota...

ea0063p192 | Diabetes, Obesity and Metabolism 1 | ECE2019

Large phenotypic variability of diabetes due to ABCC8 gene mutation illustrated by the paradigm of a family

Koufakis Theocharis , Sertedaki Amalia , Tatsi Elizabeth-Barbara , Trakatelli Christina-Maria , Karras Spyridon , Kanaka-Gantenbein Christina , Kotsa Kalliopi

Background: Monogenic Diabetes is relatively rare, representing only 1–2% of total diabetes cases; nevertheless, it is often misdiagnosed primarily as Type 1 Diabetes, leading to unnecessary insulin therapy and delayed recognition of affected family members.Methods: Case report.Results: We describe a case of a young patient who presented with hyperglycemia in the absence of ketosis and following genetic testing, he proved to h...

ea0070ep562 | Hot topics (including COVID-19) | ECE2020

A comparative evaluation of late effects of Orthodox religious fasting vs time restricted eating on metabolic profiles of overweight adults

Karras Spyridon , Koufakis Theocharis , Adamidou Lilian , Grammatiki Maria , Polyzos Stergios , Karalazou Paraskevi , Thisiadou Katerina , Zebekakis Pantelis , Makedou Kali , Kotsa Kalliopi

Background: Previous research has demonstrated positive effects of Orthodox fasting (OF) and time restricted eating (TRE) on body weight (BW). However, little is known about the late, metabolic effects of the two diets.Methods: 29 overweight adults followed a hypocaloric diet based on OF. A hypocaloric, TRE plan (eating between 08:00 to 16:00 h) was followed by 16 BW-matched participants. Anthropometric, glycemic and inflammation markers and serum lipids...

ea0056p324 | Clinical case reports - Thyroid/Others | ECE2018

Dapagliflozin and Atkins Diet in a patient with type 2 Diabetes Mellitus: A combination that should be avoided

Grammatiki Maria , Rapti Eleni , Dina Despina , Koufakis Theocharis , Antonopoulou Vasiliki , Tsekmekidou Xanthippi , Yavropoulou Maria , Karras Spyridon , Zebekakis Pantelis , Kotsa Kalliopi

Introduction: Prevalence of type 2 diabetes mellitus (T2DM) rises rapidly worldwide and most patients with T2DM are obese. All treatment algorithms advocate lifestyle modification and weight loss in combination with various therapeutic categories available for the treatment of T2DM, resulting in diet-antidiabetic drug combinations that are not always proper or safe for the patients.Case presentation: A 73-year-old Caucasian man presented to the emergency...

ea0081p579 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Association between clinical and genetic factors and glycemic and weight loss response to liraglutide in patients with type 2 diabetes

Kyriakidou Artemis , Kyriazou Angeliki V. , Koufakis Theocharis , Vasilopoulos Yiannis , Grammatiki Maria , Mellidou Eirini , RAKITZI PANTELITSA , Karaliolios Georgios , Goulis Dimitrios , Zebekakis Pantelis , Kotsa Kalliopi

Background: Previous research suggests an association between specific genetic variations and interindividual variability in response to treatment with glucagon-like receptor agonists (GLP-1 RAs) in patients with type 2 diabetes mellitus (T2DM). We aimed to evaluate the role of CTRB1/2 rs7202877 (T>G) polymorphism in glycemic control and weight loss response to liraglutide among Greek patients with T2DM and to identify clinical factors related to prediction of res...

ea0090ep136 | Calcium and Bone | ECE2023

Infection with the human immunodeficiency virus is characterized by a downregulation of the inverse relationship between irisin and parathyroid hormone independently of vitamin D status

Karras Spyridon , Koufakis Theocharis , Dimakopoulos George , Zisimopoulou Eleana , Mourampetzis Petros , Manthou Elena , Melidou Eirini , Karalazou Paraskevi , Thisiadou Katerina , Tsachouridou Olga , Zebekakis Pantelis , Makedou Kali , Metallidis Symeon , Kotsa Kalliopi

Background: Infection with the human immunodeficiency virus (HIV) predisposes to endocrine disorders, manifesting as a metabolic phenotype that affects the entire adipose-musculoskeletal unit (AMS). The present cross-sectional study aimed to investigate differences in irisin and adiponectin concentrations between people living with HIV and healthy controls, as well as to explore potential correlations between the levels of the aforementioned adipokines and markers of calcium h...

ea0063gp16 | Calcium and Bone 1 | ECE2019

The effect of parathyroidectomy on glucose homeostasis and incretin hormone release in patients with primary hyperparathyroidism: a pilot study

Antonopoulou Vasiliki , Grammatiki Maria , Koufakis Theocharis , Karras Spyridon , Yavropoulou Maria , Katsiki Niki , Gerou Spyridon , Gavana Elpida , Skoura Lemonia , Zebekakis Pantelis , Papavramidis Theodosios , Kotsa Kalliopi

Background: Primary hyperparathyroidism (PHPT) has been linked to glucose homeostasis disorders, leading to insulin resistance and type 2 diabetes mellitus. Previous small studies evaluating the effect of parathyroidectomy (PTX) on various parameters of glucose metabolism have produced conflicting results. The impact of PTX on incretin hormone levels has not been studied yet. The aim of this pilot study was to investigate the effect of PTX on markers of glucose metabolism and ...