Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep808 | Obesity | ECE2016

Increased Urocortin 3 blood levels in morbidly obese subjects are reduced after excess body weight reduction with laparoscopic sleeve gastrectomy

Bargiota Alexandra , Papamargaritis Dimitris , Sioka Eleni , Zacharoulis Dimitris , Tzovaras George , Koukoulis George

Aim: To measure Urocortin3 (Ucn3) blood levels in morbidly obese (MO) non diabetic patients before and after laparoscopic sleeve gastrectomy (LSG) for excess body weight reduction and explore its relationship with b-cell function. Ucn3 is involved in insulin secretion in the presence of nutrient excess, a key feature of obesity, and may be an integral part of the compensation of β-cells function.Methods: Nine MO patients who underwent LSG and 11 hea...

ea0022p166 | Cardiovascular endocrinology and lipid metabolism | ECE2010

CRH and Urn2 regulate NO bioavailability, ROS levels and antioxidant defence systems in endothelial cells

Gougoura Sofia , Liakos Panagiotis , Koukoulis George

Corticotropin-releasing hormone (CRH) and Urocortin 2 (Urn2) are secreted locally in peripheral tissues and play a direct immunomodulatory role as endocrine or paracrine mediators of inflammation. Studies on CRH as well as Ucn2 and vascular endothelial cells suggest that CRH may play a pivotal role in the regulation of vascular endothelial function under normal and pathological conditions. The present study was undertaken to determine whether CRH and Urn2 affect the endothelia...

ea0037ep797 | Pituitary: clinical | ECE2015

Cardiovascular risk factors and metabolic parameters in GH deficient patients

Efstathiadou Zoe A , Delaroudis Sideris P , Koukoulis George N , Kita Marina D

Introduction: GH deficiency in adulthood is associated with increased cardiovascular risk, which is attributed to unfavorable changes in body composition and in metabolic parameters.Aim: We evaluated haemodynamic, metabolic, inflammatory and coagulation indices that may contribute to the increased cardiovascular risk in GH deficient subjects.Methods: Twenty-four patients diagnosed with GH deficiency (13 male), with a mean (S...

ea0016p678 | Steroid receptors | ECE2008

Association of estrogen receptor alpha and beta gene polymorphisms with sex steroid levels in men

Sakka Christina , Efstathiadou Zoe , Polyzos Stergios , Goutou Maria , Stakias Nikolaos , Koukoulis George

Estrogens play an important role in male physiology. We investigated the possible association of four single nucleotide polymorphisms in estrogen receptor α (ER1) and Estrogen Receptor β (ER2) genes with circulating levels of sex steroids and Sex Hormone Binding Globulin (SHBG) in men.SHBG, total and calculated free testosterone (TT and cal FT), estradiol (E2) and free estradiol (FE2) were determined in a population based cohort of 170 apparent...

ea0056p950 | Female Reproduction | ECE2018

Oxidative stress markers in women with polycystic ovary syndrome without insulin resistance

Gyftaki Reveka , Gougoura Sofia , Kalogeris Nikolaos , Loi Vasiliki , Koukoulis George , Vryonidou Andromachi

Introduction: Polycystic ovary syndrome (PCOS) is usually accompanied by abdominal obesity and insulin resistance which are related with low-grade chronic inflammation, as evidenced by elevation of multiple markers of inflammation, among which is oxidative stress. However, as far as oxidative stress presence, the existing data are limited. The purpose of this study was the investigation of several oxidative stress markers in women with PCOS without insulin resistance.<p cl...