Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep618 | Diabetes therapy | ECE2017

Liraglutide restores the hyperglycemia-induced endothelial oxidative stress in vitro

Gougoura Sofia , Bargiota Alexandra , Koukoulis Georgios N

Introduction: Diabetes is characterised by increased oxidative stress and an insufficient antioxidant response, which are crucial for the initiation and progression of atherosclerosis. GLP-1 agonists, used for the treatment of diabetes, are considered as cardioprotective agents but under that concept, there are limited data on their ability to influence the endothelial antioxidant response.Methods: In order to answer this question we studied the influenc...

ea0063p614 | Diabetes, Obesity and Metabolism 2 | ECE2019

Vitamin D status and bone metabolism in adult patients with Type 1 diabetes mellitus

Barmpa Eleftheria , Karamagiolis Spyros , Tigas Stelios , Koukoulis Georgios N , Bargiota Alexandra

Introduction: Vitamin D is essential for calcium metabolism and is involved in bone turnover. The purpose of this study was to examine vitamin D status and its relation with bone metabolism in adult patients with T1DM.Methods/Design: We studied 118 patients with T1DM (Group-D) (mean age: 35.4+10.3 years) and 94 healthy controls (Group-C) matched for age, sex and body mass index (BMI). In both groups HbA1c, 25(OH)Vitamin D (Vit-D), serum calcium (Ca), pho...

ea0049ep483 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Bone mineral density in male patients with type 2 diabetes mellitus, with and without hypogonadism

Vasileiou Agathi , Karathanassi Ioanna , Navrozidou Parthena , Vlychou Marianna , Koukoulis Georgios , Bargiota Alexandra

Introduction: Type 2 diabetes mellitus (T2DM) affects bone metabolism, but its relation with bone mineral density (BMD) remains controversial. It is also known that T2DM is associated with hypogonadism in males. Male hypogonadism can also affect BMD. Thus the aim of this study was to evaluate BMD in male patients with T2DM with and without hypogonadism.Methods/design: Hypogonadism was defined as serum free Testosterone (fT) value <5 ng/dl or 5–9...

ea0035p1063 | Thyroid (non-cancer) | ECE2014

Inferior oblique muscle enlargement in a patient with Grave's orbitopathy

Tsirouki Theodora , Vasiliou Agathe , Koukoulis Georgios N , Tsironi Evaggelia , Kapsalaki Eftychia , Bargiota Alexandra

Graves’ orbitopathy (GO) is an auto-immune disorder that targets intra-orbital tissues. It is well proven to involve inflammatory hypertrophy of the rectus EOMs. Superior oblique (SO) muscle has been sporadically reported to be involved in GO. However, there are extremely few reports in the literature that refer to the involvement of the inferior oblique (IO) muscle and here we present such a case.A 33-year-old man with unilateral exophthalmos was r...

ea0035p1066 | Thyroid (non-cancer) | ECE2014

MRI evaluation of extraocular muscles in patients with Grave's orbitopathy

Tsirouki Theodora , Valvis Nikolaos , Tsironi Evaggelia , Koukoulis Georgios N , Kapsalaki Eftychia , Bargiota Alexandra

Background: Clinical evaluation of Graves’ orbitopathy (GO) is often insufficient. Frequently it is difficult to decide whether a case of GO is active, or to detect the degree of severity. STIR sequence MRI suppresses signal from fat and thus in the orbits can also detect active inflammation and oedema of extra-ocular muscles (EOMs). The aim of the present study is to examine whether imaging of rectus EOMs with STIR MRI could provide additional information for the activit...

ea0070ep273 | General Endocrinology | ECE2020

Testosterone modulates the corticotropin releasing hormone-induced pro-oxidant activity in macroendothelial cells

Filiponi Maria , Gougoura Sophia , Befani Christina , Bargiota Alexandra , Liakos Panagiotis , Koukoulis Georgios

Introduction: Limited data, support the notion that testosterone induces oxidative stress. Corticotropin-releasing hormone (CRH) participates locally in the endothelial inflammatory response by regulating the pro-oxidative mechanisms of the endothelium, inducing its adaptation to local stress. The present study was undertaken to determine whether the CRH induced pro-oxidant activity in macroendothelial cells under basal conditions, is regulated In vitro by androgen (t...

ea0070ep374 | Reproductive and Developmental Endocrinology | ECE2020

Androgen modulate the pro-oxidant and antioxidant activity of macroendothelial cells

Filiponi Maria , Gougoura Sophia , Befani Christina , Bargiota Alexandra , Liakos Panagiotis , Koukoulis Georgios

Introduction: Limited data exist on testosterone and oxidative stress induction. The present study was undertaken to evaluate, in vitro, the role of physiological concentrations of androgens (testosterone-DHT) in modulating the pro-oxidant and antioxidant activity of intact endothelial cells.Materials and methods: EA.hy926 macroendothelial cells were cultured in DMEM phenol red free without FBS for 24 hours. Growth medium was replaced and then testostero...

ea0049ep559 | Diabetes complications | ECE2017

Inhibin B levels and bone health in male adult patients with Type 1 Diabetes Mellitus

Barmpa Eleftheria , Karamagiolis Spyros , Tigas Stelios , Navrozidou Parthena , Vlychou Marianna , Fezoulidis Ioannis , Koukoulis Georgios N. , Bargiota Alexandra

Introduction: Existing data suggest that Type 1 Diabetes Mellitus (T1DM) can affect both hypothalamic-pituitary-testis axis and bone health. The mechanisms by which sex steroids influence bone remodeling remain incompletely understood. Data linking gonadal function and bone turnover in male patients with T1DM are lacking. The purpose of this study was to examine any possible association between sex steroids levels and parameters of bone assessment in male adult patients with T...

ea0041gp88 | Diabetes (1) | ECE2016

Effects of metabolic control on bone mineral density and markers of bone remodeling in adult patients with type 1 diabetes mellitus

Barmpa Eleftheria , Karamagiolis Spyros , Tigas Stelios , Navrozidou Parthena , Vlychou Marianna , Fezoulidis Ioannis , Koukoulis Georgios N. , Bargiota Alexandra

Introduction: Type 1 diabetes mellitus (T1DM) is associated with reduced bone mineral density (BMD) and increased bone turnover. However, data regarding the influence of glycemic control on bone are limited. The aim of this study was to evaluate BMD and bone remodeling markers in patients with T1DM in relation to changes in glycemic control.Methods/design: We studied 107 patients with T1DM (Group-D) (mean age: 34+8.1 years, M/F: 48/59) and 95 healthy con...

ea0041ep493 | Diabetes complications | ECE2016

The influence of glycemic control on bone mineral density and bone metabolism in patients with Type 2 Diabetes Mellitus

Barmpa Eleftheria , Karamagiolis Spyros , Tigas Stelios , Navrozidou Parthena , Vlychou Marianna , Fezoulidis Ioannis , Koukoulis Georgios N , Bargiota Alexandra

Introduction: Although patients with type 2 diabetes mellitus (T2DM) have normal or higher bone mineral density (BMD) comparing to healthy subjects, they appear to be at high risk of osteoporotic fractures. Factors that contribute to bone fragility in T2DM are not clearly understood. The aim of this study was to evaluate the influence of glycemic control on bones in T2DM.Methods/design: We studied 40 patients with T2DM (mean age: 54.3+3.2 years, M/F: 24/...