Endocrine Abstracts

Introduction: Diabetes is characterised by increased oxidative stress and an insufficient antioxidant response, which are crucial for the initiation and progression of atherosclerosis. GLP-1 agonists, used for the treatment of diabetes, are considered as cardioprotective agents but under that concept, there are limited data on their ability to influence the endothelial antioxidant response.Methods: In order to answer this question we studied the influenc...

Introduction: Vitamin D is essential for calcium metabolism and is involved in bone turnover. The purpose of this study was to examine vitamin D status and its relation with bone metabolism in adult patients with T1DM.Methods/Design: We studied 118 patients with T1DM (Group-D) (mean age: 35.4+10.3 years) and 94 healthy controls (Group-C) matched for age, sex and body mass index (BMI). In both groups HbA1c, 25(OH)Vitamin D (Vit-D), serum calcium (Ca), pho...

Graves’ orbitopathy (GO) is an auto-immune disorder that targets intra-orbital tissues. It is well proven to involve inflammatory hypertrophy of the rectus EOMs. Superior oblique (SO) muscle has been sporadically reported to be involved in GO. However, there are extremely few reports in the literature that refer to the involvement of the inferior oblique (IO) muscle and here we present such a case.A 33-year-old man with unilateral exophthalmos was r...

Background: Clinical evaluation of Graves’ orbitopathy (GO) is often insufficient. Frequently it is difficult to decide whether a case of GO is active, or to detect the degree of severity. STIR sequence MRI suppresses signal from fat and thus in the orbits can also detect active inflammation and oedema of extra-ocular muscles (EOMs). The aim of the present study is to examine whether imaging of rectus EOMs with STIR MRI could provide additional information for the activit...

Introduction: Existing data suggest that Type 1 Diabetes Mellitus (T1DM) can affect both hypothalamic-pituitary-testis axis and bone health. The mechanisms by which sex steroids influence bone remodeling remain incompletely understood. Data linking gonadal function and bone turnover in male patients with T1DM are lacking. The purpose of this study was to examine any possible association between sex steroids levels and parameters of bone assessment in male adult patients with T...

Introduction: Type 1 diabetes mellitus (T1DM) is associated with reduced bone mineral density (BMD) and increased bone turnover. However, data regarding the influence of glycemic control on bone are limited. The aim of this study was to evaluate BMD and bone remodeling markers in patients with T1DM in relation to changes in glycemic control.Methods/design: We studied 107 patients with T1DM (Group-D) (mean age: 34+8.1 years, M/F: 48/59) and 95 healthy con...

Introduction: Although patients with type 2 diabetes mellitus (T2DM) have normal or higher bone mineral density (BMD) comparing to healthy subjects, they appear to be at high risk of osteoporotic fractures. Factors that contribute to bone fragility in T2DM are not clearly understood. The aim of this study was to evaluate the influence of glycemic control on bones in T2DM.Methods/design: We studied 40 patients with T2DM (mean age: 54.3+3.2 years, M/F: 24/...

Introduction: Type 1 DM (T1DM) has been associated with low bone mineral density (BMD) measured by dual energy X-ray absorptiometry (DEXA) but not with quantitative computed tomography (QCT). QCT provides a three-dimensional image and measures bone’s volume directly as density, independent of the surrounding tissues. The purpose of this study was to evaluate BMD in patients with T1DM using DEXA and QCT.Methods/design: We studied 81 patients with T1D...

Introduction: Limited data exists regarding testosterone levels in type 1 diabetes mellitus (T1DM). The objective of this study was to evaluate serum sex steroids levels and body composition using dual energy X-ray absorptiometry method (DEXA) in male patients with T1DM.Methods/design: We studied 36 male patients with T1DM (group D) (age: 35.3+11.66, years) and 35 healthy control (group C) matched for age, sex, and BMI. In both groups waist circumference...

Background: Although IV steroids are the treatment of choice for moderate-to-severe graves orbitopathy (M-S GO), the most efficacious regimen is not yet defined. Cases not responding or relapsing after steroid treatment (STx) are not uncommon and STx can cause serious adverse events. The aim of the present study is to define the steroid regimen which balances between efficacy and damage, using stir-sequence orbital-MRI (SsMRIo) as an additional objective tool for the evaluatio...