Searchable abstracts of presentations at key conferences in endocrinology

ea0073aep449 | General Endocrinology | ECE2021

Parameters of successful telephone endocrinology consultation during covid-19 pandemic

Krajnc Mitja , Marija Kovše Krajnc

ObjectiveThe COVID-19 pandemic is an unseen international emergency causing major challenges in medical care delivery. Patients with some chronic endocrine disorders (obesity, type 2 diabetes, probably also hypertension, corticosteroid excess) have higher rates of acute COVID-19 complications and death. Due to the changes in outpatient management there is a clear danger of inadequate clinical support for endocrinology patients. The decision for face-to-f...

ea0070aep468 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The relationship between estradiol and obesity in men

Pospisilova Hana , Stárka Luboslav , Hill Martin , Dušková Michaela

Introduction: Obesity increases the incidence of hypogonadism in men, and hypogonadism in turn plays a role in obesity. One of the first mechanisms proposed to explain this was a hypothesis based on the principle that obese men have higher estrogen levels, and that increased estrogens provide feedback to the hypothalamic-pituitary-testicular axis, reducing the secretion of gonadotropins and leading to a decrease of overall testosterone levels. This concept has since been quest...

ea0014oc10.3 | Obesity & metabolism | ECE2007

Selective leptin resistance within the brainstem of histamine deficient mice

Földes Anna , Márkus Veronika , Kovács Krisztina

Histamine is an important anorexic factor that suppresses food intake via hypothalamic H1 receptors and increases energy expenditure by stimulating lipolysis. Mice with targeted deletion of the key enzyme of histamine biosynthesis, histidine decarboxylase (HDC-KO), are unable to synthesize histamine. These animals display a metabolic phenotype with adult onset obesity, selective increase in visceral fat depots, impaired glucose tolerance and hyperleptinemia. To test the possib...

ea0073aep334 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Antipsychotic induced obesity in schizophrenia and GLP-1 analog treatment? – A case-report

Iva Jakubíková , Martin Haluzík MD DSc

IntroductionSchizophrenia is one of the seven most disabling diseases according to World Health Organization. The most potent antipsychotic drugs clozapine and olanzapine are associated with excessive weight gain. Premature deaths in schizophrenia and shorter life expectancy are mainly caused by obesity-related cardiovascular diseases. Obesity itself is associated with brain deterioration, cognitive decline and overall worse quality of life. GLP-1 recept...

ea0070aep372 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The effect of SNP (rs174537) in FADS1 gene on fatty acid composition in serum lipids

Metelcová Tereza , Vaňková Markéta , Zamrazilová Hana , Hovhannisyan Milena , Tvrzická Eva , Staňková Barbora , Hill Martin , Včelák Josef , Kunešová Marie

Background: Fatty acid desaturase 1 (FADS1) gene controls the fatty acid metabolism pathway in the human body (Sergeant et al., 2012). Single nucleotide polymorphism (SNP) in FADS1 gene and percentage of polyunsaturated fatty acids inserum lipids was associated (Klingel et al., 2018). Genetically predisposition to higher plasma arachidonic and stearic acid levels were associated with incidence oflarge-artery stroke and venous thromboembolism...

ea0070ep287 | Pituitary and Neuroendocrinology | ECE2020

Obesity in endocrine connections- a finding of nonfunctional pituitary macroadenoma

Jakubíková Iva , Kratochvílová Simona , Brunová Jana , Hána Václav

Introduction: Spacious sellar area predisposes to late diagnosis of nonfunctional pituitary adenomas and in males even the functional ones such as prolactinomas. Rising prevalence of obesity is mainly associated with sedentary lifestyle and excess of food intake. Only in rare cases has endocrine etiology such as Cushing disease, hypothyroidism or hypothalamic disorders.Case-report: A 29-year-old man was admitted to our hospital for chest pain, with a hig...

ea0014p141 | (1) | ECE2007

Thyroglobulin-antibodies in the “normal” range may decrease the diagnostic accuracy of thyroglobulin in the care of patients with differentiated thyroid cancer

Zoltán Locsei , Erzsébet Toldy , István Szabolcs , Gábor Kovács L.

Issue: The use of thyroglobulin (Tg) as tumor marker in differentiated thyroid cancer (DTC) is limited in the presence of thyroglobulin-antibodies (TgAb) but it is generally believed that this is true only for TgAb concentrations over the normal ‘cut off’ point.The aim: Of this study was to investigate if TgAb-s in the normal range, considered to be physiological, may also influence the accuracy and clinical relevance of Tg measurement.<p c...

ea0011p228 | Cytokines and growth factors | ECE2006

Selected hormones serum levels in dependence on BMI and sex

Tajtáková M , Semanová Z , Petrášová D , Petroviová J , Pytliak M

Objectives: To investigate the influence of body weight and sex on serum levels of insulin, leptin, ghrelin, IGF1, adiponectin and TSH.Methods: Serum levels of insulin, IGF1, TSH and ghrelin were measured by RIA, leptin by IRMA and adiponectin by ELISA in 90 individuals (42 women, average age 49.8±8.9 years( 48 men, average age 49.1±6.6). The sample was divided into three subgroups: normal weight (BMI=15.5–24.9), excess weight (BMI=25.0&#1...

ea0070aep7 | Adrenal and Cardiovascular Endocrinology | ECE2020

Investigation of angiotensin II induced gene expression changes in vascular smooth muscle cells

Balla András , Szalai Laura , Gém Janka , Kovács Kinga , Szakadáti Gyöngyi , Hunyady László

The angiotensin II (AngII) hormone exerts a number of biological effects through the type 1 angiotensin II receptor (AT1R). One of the main targets of AngII are vascular smooth muscle cells, their stimulation activates many signaling pathways and results in gene expression changes.Affymetrix Gene Chip experiments were performed to analyze the effects of AngII stimulation on gene expression. For the determinations, aortic thoracic aorta from young male Wi...

ea0070aep371 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The influence of obesity on changes in adipokines during the menstrual cycle

Šrámková Monika , Kolátorová Lucie , Včelák Josef , Lischkova Olga , Stárka Luboslav , Dušková Michaela

The purpose of the menstrual cycle is to prepare the egg for fertilization and implantation. The changes and functions of the basic steroid hormones during the menstrual cycle are well known. However, changes to other hormones occur during the menstrual cycle as well, including those influencing the intake of food. These changes have been described inconsistently in the literature, especially considering differences in overweight and obese women. The aim of this study was to d...