Searchable abstracts of presentations at key conferences in endocrinology

ea0022s9.2 | The role of oxidative stress in the development of the metabolic syndrome | ECE2010

Macrophage dysfunction and insulin resistance

Kovanen Petri T

Obesity and associated insulin resistance are associated with increased numbers of infiltrating macrophages at various sites of white adipose tissue. The adipose tissue macrophages are considered to be a major cause of obesity-associated chronic low-grade inflammation. The macrophages present in adipose tissue secrete a wide variety of proinflammatory molecules including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1)...