Searchable abstracts of presentations at key conferences in endocrinology

ea0035p158 | Calcium and Vitamin D metabolism | ECE2014

Evaluation of the relationship between vitamin D concentration and selected clinical and biochemical features in women with polycystic ovary syndrome

Szymonek Monika , Kowalska Aldona

Introduction: Vitamin D deficiency (25OHD) is common in women with polycystic ovary syndrome (PCOS). 67–85% of female patients with PCOS have low concentration level of 25OHD (<20 ng/ml). It is believed that low concentration levels of 25OHD may exacerbate the symptoms of PCOS.Aim: The aim of the study was to evaluate the concentration of 25OHD in women diagnosed with PCOS and the analysis of the relationship between 25OHD concentration and such...

ea0035p1067 | Thyroid (non-cancer) | ECE2014

Successful preoperative treatment of toxic nodular goiter patient with agranulocytosis using plasmapheresis

Trybek Tomasz , Kowalska Aldona

Agranulocytosis is an uncommon but very serious complication during treatment with thyrostatic. In case of severe hyperthyroidism removal of circulating thyroid hormones by plasmapheresis may be an effective therapeutic option.We present the therapeutic difficulties and successful treatment with preoperative plasmapheresis in 63-year-old female patient with severe hyperthyroidism in the course of toxic nodular goiter and agranulocytosis, which occurred a...

ea0020p316 | Clinical case reports and clinical reports | ECE2009

Malignant pheochromocytoma with brain metastases and coexisting meningioma: case report

Kowalska Aldona , Lizis-Kolus Katarzyna

Introduction: Pheochromocytoma is usually benign neuroendocrine tumor arising from chromaffin cells. Malignant tumors which account for 5–26% mainly metastize to bones, lungs, liver, but very rarely to brain. The coexistence of pheochromocytoma with brain meningioma may hinder the diagnosis.Aim: The aim of this study is to present the case of a malignant pheochromocytoma female with brain metastases and coexisting meningioma.C...

ea0049ep1442 | Thyroid (non-cancer) | ECE2017

Malignancy risk stratification in thyroid nodules according to the Bethesda system for reporting thyroid cytopathology

Kowalska Aldona , Suligowska Agnieszka , Kopczynski Janusz , Niemyska Kornelia , Gozdz Stanislaw

Introduction: Fine needle aspiration biopsy (FNAB) plays a crucial role in the diagnosis of thyroid nodules. The choice of further therapeutic strategy depends largely on its result. Knowledge of the risk of malignancy in each diagnosis class in the population is necessary. The aim of the research was to analyse the risk of malignancy in thyroid nodules in each diagnosis class according to Bethesda system.Materials and methods: Retrospective research inc...

ea0035p319 | Clinical case reports Thyroid/Others | ECE2014

The unusual case of the appearance of radioiodine (I-131) uptake in lung metastases in a patient with papillary thyroid cancer (PTC)

Palyga Iwona , Kowalska Aldona , Walczyk Agnieszka , Holody Lukasz

A 67-year-old male with PTC (pT3N0) underwent a total thyroidectomy in February 2004. Subsequently he was treated with I-131 and radiotherapy (RT). Combined therapy did not normalize the serum thyroglobulin (TG). Because of elevated TG and persistent I-131 uptake in thyroid bed the patient received a total activity of 21275 MBq of I-131 in 4 years. The treatment was stopped in March 2007 due to a lack of I-131 uptake in the last post-therapeutic whole body scan (WBS) with stil...

ea0028p246 | Pituitary | SFEBES2012

High prevalence of pituitary adenomas in patients with Macroprolactinaemia and oligo-/amenorrhoea

Gasior-Perczak Danuta , Lewandowski Krzysztof , Kowalska Aldona , Lewinski Andrzej

Background: The so called “big-big” prolactin, also known as macroprolactin is formed by prolactin-immunoglobulin complexes, and is considered to be biologically inactive. Nevertheless, macroprolactin may cause elevation of serum prolactin (Prl) concentrations measured by standard assays. In women presenting with oligo- and/or amenorrhoea the cause of menstrual irregularity needs to be explained even in the setting of concomitant macroprolactinaemia. We have therefor...

ea0028p361 | Thyroid | SFEBES2012

Prevalence of macroprolactinaemia in regularly menstruating women with non-toxic goitre or autoimmune thyroid disease

Lewandowski Krzysztof , Gasior-Perczak Danuta , Kowalska Aldona , Lewinski Andrzej

Macroprolactin is formed by prolactin-immunoglobulin complexes and may cause elevation of prolactin (Prl) concentrations, potentially leading to unnecessary investigations and/or treatment. We have endeavoured to assess the prevalence of macroprolactinaemia in euthyroid women with non-toxic goitre and to assess whether autoimmune thyroid disease may result in an increased prevalence of macroprolactinaemia.Material & Methods: We measured serum Prl in ...

ea0016p474 | Neuroendocrinology | ECE2008

Macroprolactinaemia: a clinical problem

Kowalska Aldona , Gasior-Perczak Danuta , Palyga Iwona , Sluszniak Anna

Introduction: Prolactin is a hormone which is characterized with a high structural and functional polymorphism. Macroprolactin is one of the form of prolactin - it is a complex of monomeric prolactin and immunoglobulin. Macroprolactin is characterized with immunoreactivity and probably the lack of biological activity.Purpose: The main purpose of our study was to estimate the frequency of macroprolactin appearance among the patients with hyperpronactinaem...

ea0049ep1297 | Thyroid (non-cancer) | ECE2017

The assessment of influence vitamin D deficiency on the Hashimoto’s thyroiditis activity

Lizis-Kolus Katarzyna , Hubalewska-Dydejczyk Alicja , Sowa-Staszczak Anna , Skalniak Anna , Kowalska Aldona , Lizis Pawel

: The observed increase in the incidence of Hashimoto’s thyroiditis (HT) requires research on factors that may affect its development. One of them may be vitamin D deficiency which is an epidemiological problem all over the world.Aim: The assessment of influence vitamin D deficiency on the HT activity.Material and methods: 310 people were enrolled in the study: 155 patients with HT (a-TPO and/or a-TG positivity)-144 women (93%...

ea0041gp227 | Thyroid Cancer | ECE2016

Is ultrasensitive Tg measurement capable of substituting for Tg measurement after rhTSH stimulation in evaluation of effectiveness of radioiodine ablation in patients with differentiated thyroid cancer

Kowalska Aldona , Gasior-Perczak Danuta , Palyga Iwona , Trybek Tomasz , Sluszniak Anna

Introduction: Undetectable concentration of Tg after rhTSH stimulation (Tg/rhTSH) is one of the most important criteria in evaluating the effectiveness of radioiodine ablation in patients with differentiated thyroid cancer (DTC) treated with 131I.Aim: To evaluate the possibility of using L-T4 suppression treatment (Tg/L-T4) measurements by the ultrasensitive method TRACE (immunofluorescence method) with the KRYPTOR analyzer instead of the Tg/rhTSH measur...