Searchable abstracts of presentations at key conferences in endocrinology

ea0081p714 | Reproductive and Developmental Endocrinology | ECE2022

Serum concentrations of 17-hydroxyprogesterone and dehydroepiandrosterone sulfate in women with polycystic ovary syndrome and their relation to the parameters of glucose metabolism

Stogowska Ewa , Krentowska Anna , Adamska Agnieszka , Lebkowska Agnieszka , Kowalska Irina

Introduction: Polycystic ovary syndrome (PCOS) is characterized by menstrual disorders, hyperandrogenism and polycystic ovaries on ultrasonography. This hormonal disorder is also strongly associated with insulin resistance. The diagnosis of PCOS can be established after the exclusion of other causes of mentioned symptoms, such as non-classic congenital adrenal hyperplasia (NCAH). To date, several studies suggest the increased serum concentration of 17-hydroxyprogesterone (17-O...

ea0041ep265 | Clinical case reports - Pituitary/Adrenal | ECE2016

Late complications in a man with poorly controlled congenital adrenal hyperplasia – case report

Maliszewska Katarzyna , Kowalska Irina , Poplawska-Kita Anna , Gorska Maria

Introduction: We report a case of CAH who developed several complications due to poor control. Proper diagnosis and treatment can enable men with the disease to have a normal life and fertility. Case report 39-year-old patient with a history of primary adrenal insufficiency was admitted to our department because of infertility. Semen analysis performed prior to hospitalization showed azoospermia. The patient did not have medical documentation regarding his disease and was not ...

ea0020p278 | Clinical case reports and clinical reports | ECE2009

Cushing syndrome caused by topical corticosteroids coexistent with pituitary incidentaloma – case report

Karczewska-Kupczewska Monika , Adamska Agnieszka , Kowalska Irina , Gorska Maria

Iatrogenic Cushing syndrome caused by the use of steroid medications is common because of the widespread use of these medications for the treatment of many diseases, however development of Cushing syndrome from the topical corticosteroids is very rare in adults.A 45-year-old men (BMI: 44 kg/m2), with a history of psoriasis, developed manifestations of Cushing syndrome, which included weight gain, central obesity, moon face, facial plethora, bu...

ea0049ep1104 | Female Reproduction | ECE2017

Serum concentrations of betatrophin and its association with indirect indices of insulin resistance and beta cell function in women with polycystic ovary syndrome

Adamska Agnieszka , Lebkowska Agnieszka , Jacewicz Malgorzata , Krentowska Anna , Hryniewicka Justyna , Wolczynski Slawomir , Gorska Maria , Kowalska Irina

The accumulated data underline the role of betatrophin in glucose homeostasis. Polycystic ovary syndrome (PCOS) is characterized by insulin resistance and high risk of developing prediabetes and diabetes. The aim of our study was to investigate the relationship of serum betatrophin concentrations with indirect indices of insulin resistance and insulin secretion in women with PCOS, comparing to the control group. The study group comprised 43 women with PCOS and 16 controls matc...

ea0070aep797 | Reproductive and Developmental Endocrinology | ECE2020

Ovarian reserve and serum concentration of thyroid peroxidase antibodies in euthyroid women with different polycystic ovary syndrome phenotypes

Adamska Agnieszka , Lebkowska Agnieszka , Krentowska Anna , Pliszka Justyna , Adamski Marcin , Leśniewska Monika , Kowalska Irina

Objective: It has been shown that women with PCOS as well as with autoimmune thyroiditis (AIT), are characterized by increased incidence of infertility. Serum anti-Müllerian hormone (AMH), which reflects ovarian reserve, is elevated in PCOS women and is decreased in women with AIT. The Rotterdam criteria recognize four clinical PCOS phenotypes,i.e.,phenotype Acharacterized by clinical and/or biochemical hyperandrogenism (HA), menstrual dysfunction (oligo/amenorrhea) (Olig...

ea0032p346 | Diabetes | ECE2013

Elevation of circulating free fatty acids abolishes down-regulation of skeletal muscle adiponectin receptor 1 (AdipoR1) expression caused by insulin infusion

Straczkowski Marek , Karczewska-Kupczewska Monika , Adamska Agnieszka , Stefanowicz Magdalena , Matulewicz Natalia , Kowalska Irina , Nikolajuk Agnieszka

Introduction: Adiponectin is an adipocytokine with insulin-sensitizing and anti-inflammatory properties. In skeletal muscle, it increases fatty acid oxidation and insulin-stimulated glucose uptake through binding with adiponectin receptor 1 (AdipoR1). The aim of our study was to assess the effect of insulin and Intralipid/heparin infusions on muscle AdipoR1 expression in humans.Methods: Twenty healthy male subjects (age 25.2±3.2 years; BMI, 26.5&#17...

ea0032p351 | Diabetes | ECE2013

Skeletal muscle and adipose tissue glycoprotein 130 expression is associated with insulin resistance in humans

Karczewska-Kupczewska Monika , Nikolajuk Agnieszka , Adamska Agnieszka , Matulewicz Natalia , Stefanowicz Magdalena , Kowalska Irina , Straczkowski Marek

Introduction: Glycoprotein 130 (gp130) cytokines, like interleukin 6 (IL6), act through plasma membrane receptors consisting of two glycoproteins: a cytokine binding subunit (like IL6R) and gp130, responsible for signal transduction. IL6 may regulate insulin sensitivity in a dual manner, as both insulin-sensitizing and -desensitizing actions have been reported. Other gp130 cytokines may have a beneficial metabolic effects. The aim of the present study was to assess skeletal mu...

ea0032p735 | Obesity | ECE2013

Serum IL18 concentration is associated with resting energy expenditure independently of BMI

Nikolajuk Agnieszka , Adamska Agnieszka , Karczewska-Kupczewska Monika , Matulewicz Natalia , Stefanowicz Magdalena , Kowalska Irina , Straczkowski Marek

Introduction: Numerous studies indicate an association between low-grade chronic inflammation and predisposition to type 2 diabetes and atherosclerosis. IL18 is a proinflammatory cytokine with proatherogenic properties. Existing evidence indicated that circulating IL18 was associated with insulin resistance, metabolic syndrome and type 2 diabetes. Some data suggest that endogenous IL18 signaling modulates food intake, metabolism and adiposity, as homeostatic regulator. The aim...

ea0022p345 | Diabetes | ECE2010

Decreased serum brain-derived neurotrophic factor concentration in young nonobese subjects with low insulin sensitivity

Karczewska-Kupczewska Monika , Adamska Agnieszka , Nikolajuk Agnieszka , Otziomek Elzbieta , Gorska Maria , Straczkowski Marek , Kowalska Irina

Insulin resistance and type 2 diabetes are associated with an increased risk of neurodegenerative diseases. Brain-derived neurotrophic factor (BDNF) regulates neuronal differentiation and synaptic plasticity and its decreased levels are supposed to play a role in the pathogenesis of Alzheimer disease and other disorders. Decreased circulating BDNF levels in obesity and type 2 diabetes were reported, however, it is unclear, whether BDNF might be associated with insulin resistan...

ea0020p446 | Obesity and Metabolism | ECE2009

Serum visfatin concentration in obesity and impaired glucose tolerance – relationship with insulin resistance, blood pressure and proinflammatory factors

Kowalska Irina , Straczkowski Marek , Nikolajuk Agnieszka , Karczewska-Kupczewska Monika , Adamska Agnieszka , Gorska Maria

Visfatin, a protein secreted by the adipose tissue, might regulate insulin action. The aim of the present study was to assess serum visfatin concentration in obese women with normal glucose tolerance (NGT) and impaired glucose tolerance (IGT) and to estimate the relationships between serum visfatin concentration and insulin sensitivity, blood pressure, proinflammatory and proatherogenic factors.The study group consisted of 134 women: 30 overweight or obe...