Endocrine Abstracts

Introduction: Recent studies have elucidated that C-type natriuretic peptide (CNP), a member of natriuretic peptide family, is a potent stimulator of endochondral bone growth; CNP and its membranous guanylyl cyclase receptor, GC-B are expressed in growth plate, and mice with targeted overexpression of CNP in growth plate exhibit prominent skeletal overgrowth, whereas CNP or GC-B knockout mice develop severely short stature phenotype owing to their impaired endochondral bone gr...