Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1292 | Paediatric endocrinology | ICEECE2012

Systemic administration of C-type natriuretic peptide rescues impaired endochondral bone growth in mice model of achondroplasia

Yasoda A. , Fujii T. , Kondo E. , Nakao K. Koyama N. , Yamashita Y. , Ueda Y. , Kanamoto N. , Sone M. , Miura M. , Arai H. , Nakao K.

Introduction: Recent studies have elucidated that C-type natriuretic peptide (CNP), a member of natriuretic peptide family, is a potent stimulator of endochondral bone growth; CNP and its membranous guanylyl cyclase receptor, GC-B are expressed in growth plate, and mice with targeted overexpression of CNP in growth plate exhibit prominent skeletal overgrowth, whereas CNP or GC-B knockout mice develop severely short stature phenotype owing to their impaired endochondral bone gr...