Searchable abstracts of presentations at key conferences in endocrinology

ea0077lb10 | Late Breaking | SFEBES2021

Interpreting hyponatraemia in the wider context and the use of desmopressin outside of endocrinology

Koysombat Kanyada , Zac-Varghese Sagen

Hyponatraemia is the most commonly encountered electrolyte disturbance seen in 15-20% of inpatients. Regardless of severity, hyponatraemia is associated with increased length of stay, morbidity and mortality. We describe a case of a 60-year-old patient admitted with recurrent falls, head injury and hyponatraemia on a background of young-onset Parkinson’s disease with predominant cognitive decline, bladder disturbances and autonomic failure. Following multiple treatments f...

ea0074ncc35 | Highlighted Cases | SFENCC2021

Challenges in managing toxic multinodular goitre and propylthiouracil-induced anti-neutrophil cytoplasmic antibody associated vasculitis

Koysombat Kanyada , Rehman Zahra , Aung Htet Htet , Elmustafa Sarra , Lin Nyan , Zac-Varghese Sagen , Solomon Andrew

Case history: A 53-year-old woman presented with vasculitic rash affecting her limbs. She has a 3-year history of thyrotoxicosis. Having developed intolerance to carbimazole she was maintained on propylthiouracil (PTU) for the last two years. Imaging results were consistent with multinodular goitre. Thyroid stimulating immunoglobulin was negative. A few months prior to this presentation she developed dysphagia. Repeat imaging showed an 8 cm right thyroid nodule that grew signi...

ea0094p116 | Reproductive Endocrinology | SFEBES2023

Patient and healthcare providers experience of access to menopause-related information and menopause-care provision across the UK: Results from a nationwide survey

Koysombat Kanyada , Pedder Hugo , Vinogradova Yana , Qayum Ambreen , N Comninos Alexander , Talaulikar Vikram , Panay Nick , S Dhillo Waljit , Mukherjee Annice , Abbara Ali

Menopause management guidelines advocate a personalised, evidence-based approach to menopause-care. This study explored the current landscape of menopause-care, from both patients’ and healthcare-providers’ perspectives, to better understand barriers to menopause-care across the UK.Methods: A 25-question online patient-survey and a 23-question GP-survey was designed with individuals with lived-experience of menopause to underst...

ea0099p551 | Reproductive and Developmental Endocrinology | ECE2024

Endocrine responses to kisspeptin in an unusual case of kallmann syndrome with unilateral anosmia

Tsoutsouki Jovanna , N Comninos Alexander , Phylactou Maria , Patel Bijal , Mills Edouard , Young Megan , Yeung Arthur , Koysombat Kanyada , Modi Manish , Papadopoulou Deborah , Howard Sasha , S Dhillo Waljit , Abbara Ali

Introduction: Kallmann syndrome (KS) is a rare condition characterised by congenital hypogonadotropic hypogonadism (CHH), usually due to defective migration of olfactory axons and GnRH-neurons. KS is typically associated with absent (anosmia) or reduced (microsmia) sense of smell. Unilaterally hypoplastic or absent olfactory bulbs on MRI are reported, although disturbance in smell is usually bilateral. Kisspeptin is a potent stimulator of hypothalamic GnRH-neurons, and endocri...

ea00100oc1 | Oral Communications | SFEEU2024

Making scents of hemi-anosmia in a woman presenting with secondary amenorrhoea

Tsoutsouki Jovanna , Comninos Alexander N , Phylactou Maria , Young Megan , Mills Edouard , Maria Newman Anastasia , Wynn Nyunt Sandhi , Koysombat Kanyada , Yeung Arthur , Patel Bijal , Howard Sasha , S Dhillo Waljit , Abbara Ali

Case history: A 25-year-old woman presented with secondary amenorrhoea present since aged 18yrs. She had spontaneous albeit late menarche aged 16yrs and five menstrual periods over the subsequent two-years, before complete menstrual cessation. She denied other medical history, psychological stress, excessive exercise, or regular medications. Notably, she reported normal sense of smell via her right nostril, but anosmia via her left nostril. Family history included a diagnosis ...

ea00100p21 | Poster Presentations | SFEEU2024

Reversal of congenital hypogonadotrophic hypogonadism (CHH) in a woman with a heterozygous inactivating variant in GnRHR gene

W Nyunt Sandhi , Phylactou Maria , Koysombat Kanyada , Tsoutsouki Jovanna , C Yeung Arthur , Young Megan , Newman Anastasia , N Comninos Alexander , Mamoojee Yaasir , Pitteloud Nelly , Quinton Richard , S Dhillo Waljit , Abbara Ali

Case history: Our patient presented with primary amenorrhoea and incomplete puberty aged 15 yrs. Based on BMI >40 kg/m2 from early adolescence, clinical hyperandrogenism, family history of polycystic ovary syndrome (PCOS), and insulin resistance, she was diagnosed with PCOS and commenced on a combined oral contraceptive (COC), achieving breast development. Aged 21yrs, she was reassessed for amenorrhoea of COC. Biochemical assessment revealed hypogonadotrophic hy...

ea0099oc1.4 | Oral Communications 1: Reproductive and Developmental Endocrinology | ECE2024

Kisspeptin as a test of hypothalamic function in women presenting with oligo / amenorrhoea

Patel Bijal , Abbara Ali , Yeung Arthur , Phylactou Maria , Tsoutsouki Jovanna , Koysombat Kanyada , Young Megan , Nyunt Sandhi , Qayum Ambreen , Patel Aaran , Zielinska Agata , Omar Yusra , Eng Pei , Mills Edouard G , Hanassab Simon , Webber Lisa , Jayasena Channa , Tan Tricia , Quinton Richard , Clarke Sophie , Comninos Alexander , Dhillo Waljit

Background: Polycystic Ovary Syndrome (PCOS) and Functional Hypothalamic Amenorrhoea (FHA) are the two commonest causes of menstrual disturbance in pre-menopausal women. In practice, differentiating these two common reproductive disorders can be challenging. A fundamental abnormality that underpins both conditions is altered gonadotrophin releasing hormone (GnRH) pulsatility, being increased in PCOS but reduced in FHA. Likewise, congenital (e.g. congenital hypogonadotropic hyp...