Searchable abstracts of presentations at key conferences in endocrinology

ea0041gp53 | Cardiovascular endocrinology | ECE2016

Different repletion of intramyocellular lipid (IMCL) in patients with growth hormone deficiency (GHD) compared to control subjects (CS) 24 h after a 2-h aerobic exercise

Jenni Stefan , Loher Hannah , Bucher Julie , Ith Michael , Boesch Chris , Kreis Roland , Christ Emanuel R

Background: We and others have shown that ectopic lipids are flexible fuel stores in healthy subjects, in patients with type 1 diabetes or with GHD. IMCL are depleted by exercise and repleted by diet, whereas intrahepatocellular lipids (IHCL) are increased immediately after exercise. It is unclear whether the exercise-induced flexibility of IMCL and IHCL persists until 24 h and whether healthy subjects and patients with GHD behave differently.Methods: Ma...

ea0035p200 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Flexibility of ectopic lipids in physically active, healthy individuals

Bucher Julie , Krusi Marion , Kreis Roland , Zuger Thomas , Ith Michael , Stettler Christoph , Boesch Chris

Introduction: Ectopic lipids are fuel stores in non-adipose tissues (i.e. skeletal muscle (IMCL), liver (IHCL), heart (ICCL)). An aerobic-exercise bout leads to a decrease in IMCL (‘working tissues’), whereas it is not established whether a single but of exercise influences IHCL or ICCL.Increased IMCL and IHCL have been related to impaired insulin action in skeletal muscle and liver. It is hypothesized that fat availability (subcutaneous and vi...

ea0032p180 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

The effect of aerobic exercise on ectopic lipids intramyocellular, intrahepatocellular, and intracardiomyocellular lipids in physically active, healthy individuals

Kruesi Marion , Bucher Julie , Kreis Roland , Ith Michael , Zueger Thomas , Stettler Christoph , Boesch Chris , Christ Emanuel

Introduction: Ectopic lipids are fuel stores in non-adipose tissues (i.e. skeletal muscle (IMCL), liver (IHCL), and heart (ICCL)). It is recognized that IMCL can be depleted by physical activity and repleted by dietary fat intake indicating metabolic flexibility. In contrast, preliminary data suggested that aerobic exercise increases IHCL. Data on the acute effect of aerobic exercise on ICCL is scarce.Increased IMCL and IHCL have consistently been relate...

ea0022p306 | Diabetes | ECE2010

Exercise-related levels of acetylcarnitine in skeletal muscle of individuals with type 1 diabetes in Eu- and hyperglycaemia assessed by 1H-MR spectroscopy

Jenni Stefan , Boss Andreas , Kreis Roland , Ith Michael , Christ Emanuel , Boesch Chris , Stettler Christoph

Background: Acetylcarnitine (AC) is involved in intramyocellular fuel metabolism during exercise. So far, little is known on exercise-associated myocellular AC levels in patients with type 1 diabetes. In particular, it is unknown whether AC levels differ according to glucose values in diabetic patients. 1H magnetic resonance spectroscopy (MRS) of the skeletal muscle allows for the non-invasive assessment of acetylcarnitine (AC) accumulation. The present study assess...